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ProteomicsIn vitro expanded and activated polyclonal γδ memory T cells for treatment of cancer
γδ-T lymphocytes are cells of the innate immune system exerting potent natural cytotoxicity against bacteria, viruses and tumours. This ability, coupled with their negligible alloreactivity, makes them attractive for adoptive immunotherapy approaches. To achieve a cell product suitable for clinical ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-18 | PXD015506 | Pride
Γδ t cells cancer 
ProteomicsConcert between cytokines and costimulatory domains to optimize chimeric antigen receptor immunotherapy in neuroblastoma model
Adoptive T cell therapy with gene-modified T cells expressing chimeric antigen receptor (CAR) is a rapidly growing field of translational medicine and recently has shown dramatic therapeutic success in the treatment of B-cell malignancies. However, challenges to achieve similar response in patients ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-27 | PXD005426 | Pride
Human Phosphoproteomics Car Lc-ms/ms 
ProteomicsHuman γδ T-cell, LC-MS/MS - Zoledronic acid boosts γδ T-cell activity in children receiving αβ+ T and CD19+ cell-depleted grafts from an HLA-haplo-identical donor
A new method of graft manipulation based on physical removal of αβ+ T cells and CD19+ B cells, leaving mature NK cells and γδ T cells in the graft, has been recently developed for HLA-haploidentical HSCT. We demonstrated that γδ T cells collected from transplanted patients are endowed with capacity ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002629 | Pride
Human Γδ t-cell Leukemia cells Zolendric acid (zol) 
TranscriptomicsTranscription profiling of human blood from chronic lymphocytic leukemia patients before and after Fludarabine treatment
Transcription profiling of blood from human chronic lymphocytic leukemia patients before and after Fludarabine treatment
ORGANISM(S): Homo sapiens 
2010-09-01 | E-TABM-825 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of blood from human chronic lymphocytic leukemia patients before and after Fludarabine treatment
Molecular profile of Fludarabine refractory and sensitive CLLs
ORGANISM(S): Homo sapiens 
2010-09-01 | E-TABM-824 | biostudies-arrayexpress
UnknownOral contraceptives combined with interferon β in multiple sclerosis.
Not available
S-EPMC4476053 | biostudies-literature
UnknownCancer Stem Cell-Based Models of Colorectal Cancer Reveal Molecular Determinants of Therapy Resistance.
Not available
S-EPMC4798739 | biostudies-literature
ProteomicsMass spectrometry-based draft of the mouse proteome
Quantitative draft map of the proteomes of 41 healthy tissues of the animal model Mus musculus and a panel of 66 murine pancreatic ductal adenocarcinoma cell lines and. Our in-depth analysis provides evidence for proteins encoded by >16,000 genes (~76% of the total annotated protein-coding genes), w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-09 | MSV000089856 | MassIVE
TranscriptomicsExpression data from mitochondrial protease ClpP knock-out mice.
The peptidase ClpP is conserved from bacteria to human. In the mitochondrial matrix, it multimerizes and forms a macromolecular proteasome-like cylinder. Because of its known relevance for the mitochondrial unfolded protein response during cell stress, we characterized two ClpP knock-out mouse found...
ORGANISM(S): Mus musculus 
2013-07-17 | E-GEOD-40207 | biostudies-arrayexpress
UnknownThrombolysis after dabigatran reversal: A nation-wide Italian multicentre study, systematic review and meta-analysis.
Not available
S-EPMC10069212 | biostudies-literature
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