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MetabolomicsComprehensive lipid analysis of green Arabica coffee beans by LC-HRMS/MS
Lipids play an important role in coffee bean development, coffee brew and in the effects of coffee on human health. They account for around 17% of the dry bean weight and encompass different classes and subclasses, mostly triacylglycerols (TAG) and a minor quantity of phospholipids (PL) and βN-alkan...
2021-11-19 | MTBLS1972 | MetaboLights
UnknownA functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis.
The ST2/IL33 signalling pathway has been associated with ulcerative colitis (UC). ST2, encoded by the IL1RL1 gene, is expressed as both a membrane-anchored receptor (ST2L) activated by IL33 and as a soluble receptor (sST2) with anti-inflammatory properties. In UC patients, sST2 is further increased ...
S-EPMC5579262 | biostudies-literature
UnknownDiagnostic classification of irritability and oppositionality in youth: a global field study comparing ICD-11 with ICD-10 and DSM-5.

Background

Severe irritability has become an important topic in child and adolescent mental health. Based on the available evidence and on public health considerations, WHO classified chronic irritability within oppositional defiant disorder (ODD) in ICD-11, a solution markedly different fro...
S-EPMC7657976 | biostudies-literature
UnknownTranscriptomic profiles of aging in purified human immune cells.

Background

Transcriptomic studies hold great potential towards understanding the human aging process. Previous transcriptomic studies have identified many genes with age-associated expression levels; however, small samples sizes and mixed cell types often make these results difficult to inte...
S-EPMC4417516 | biostudies-literature
UnknownEngineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity.
A key effector route of the Sugar Code involves lectins that exert crucial regulatory controls by targeting distinct cellular glycans. We demonstrate that a single amino-acid substitution in a banana lectin, replacing histidine 84 with a threonine, significantly reduces its mitogenicity, while prese...
S-EPMC4641746 | biostudies-literature
UnknownGenomic insights into the Ixodes scapularis tick vector of Lyme disease.
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumu...
S-EPMC4748124 | biostudies-literature
UnknownDual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF).

Aims

Although the focus of therapeutic intervention has been on neurohormonal pathways thought to be harmful in heart failure (HF), such as the renin-angiotensin-aldosterone system (RAAS), potentially beneficial counter-regulatory systems are also active in HF. These promote vasodilatation a...
S-EPMC3746839 | biostudies-literature
UnknownGenome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association st...
S-EPMC11396662 | biostudies-literature
UnknownData-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool.

Importance

Test accuracy studies often use small datasets to simultaneously select an optimal cutoff score that maximizes test accuracy and generate accuracy estimates.

Objective

To evaluate the degree to which using data-driven methods to simultaneously select an optimal Patient Heal...
S-EPMC11584932 | biostudies-literature
UnknownResearch priorities to reduce the impact of COVID-19 in low- and middle-income countries.

Background

The COVID-19 pandemic has caused disruptions to the functioning of societies and their health systems. Prior to the pandemic, health systems in low- and middle-income countries (LMIC) were particularly stretched and vulnerable. The International Society of Global Health (ISoGH) so...
S-EPMC9010705 | biostudies-literature
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