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MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Xenograft assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS730 | MetaboLights
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Stem cell and cell line assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS4708 | MetaboLights
TranscriptomicsRNA-seq analysis reveals significant effects of EGFR signaling on mesenchymal stem cells (MSC)
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goal of this study is to analyse the whole transcriptome of MSCs stimulated with TGFα in order to comprehensively assess the genes regulated by EGFR signalling Methods: Libraries of cDNA wer...
ORGANISM(S): Homo sapiens 
2015-06-26 | E-GEOD-60560 | biostudies-arrayexpress
TranscriptomicsAtrial Myxomas Arise From Multipotent Myxoid Cardiac Stem Cells
Myxomas, the most common primary tumor of the heart, usually develop in the atria and consist of a myxoid matrix composed of an acid-mucopolysaccharide-rich stroma with polygonal stromal cells scattered throughout the matrix. These benign tumors, despite their rarity, are a research focus because of...
ORGANISM(S): Homo sapiens 
2020-05-02 | E-MTAB-8642 | biostudies-arrayexpress
TranscriptomicsAtrial Myxomas Arise From Multipotent Myxoid Cardiac Stem Cells
Myxomas, the most common primary tumor of the heart, usually develop in the atria and consist of a myxoid matrix composed of an acid-mucopolysaccharide-rich stroma with polygonal stromal cells scattered throughout the matrix. These benign tumors, despite their rarity, are a research focus because of...
ORGANISM(S): Homo sapiens 
2020-04-01 | E-MTAB-8701 | biostudies-arrayexpress
UnknownRepurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype
Batten diseases (BDs) are a group of lysosomal storage disorders characterized by seizure, visual loss, and cognitive and motor deterioration. We discovered increased levels of globotriaosylceramide (Gb3) in cellular and murine models of CLN3 and CLN7 diseases and used fluorescent-conjugated bacteri...
S-SCDT-EMM-2020-13742 | biostudies-other
UnknownMiR-182-3p targets TRF2 and impairs tumor growth of triple negative breast cancer
The Telomeric Repeat-binding Factor 2 (TRF2) is a telomere-capping protein that plays a key role in the maintenance of telomere structure and function. It is highly expressed in different cancer types and it contributes to cancer progression. To date, anti-cancer strategies to target TRF2 remain a c...
S-SCDT-10_15252-EMMM_202216033 | biostudies-other
UnknownThe impact of vaccination status on post-acute sequelae in hospitalized COVID-19 survivors using a multi-disciplinary approach: An observational single center study.

Background

COVID-19 vaccines reduced mortality, hospitalizations and ICUs admissions. Conversely, the impact of vaccination on Long COVID-19 syndrome is still unclear. This study compared the prevalence of post-acute sequelae at short and long-term follow-up among hospitalized unvaccinated a...
S-EPMC11617281 | biostudies-literature
UnknownErgonomics in the operating room and surgical training: a survey on the Italian scenario.

Introduction

Surgical-related injuries are frequent, in fact the reported percentage of musculoskeletal disorders in surgeons is between 47% and 87%. These conditions are caused by long periods of standing, incorrect postures, repeated movements, little rest between operations, the lack of i...
S-EPMC11337608 | biostudies-literature
UnknownThe role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic.
Specific immune suppression types have been associated with a greater risk of severe COVID-19 disease and death. We analyzed data from patients >17 years that were hospitalized for COVID-19 at the "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico" in Milan (Lombardy, Northern Italy). The st...
S-EPMC10513414 | biostudies-literature
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