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piRNA-deficient Maelstrom (Mael) null mice are characterized by a strong upregulation of retrotransposon LINE-1 (L1) in meiotic spermatocytes. This defect turns out in the accumulation of L1 RNA and ORF1p in their cytoplasm and the formation of prominent ribonucleoprotein aggregates. We used 3-month...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-26 | PXD039425 | Pride
We have previously demonstrated (Calura E et al., 2013) that different epithelial ovarian cancer (EOC) histotypes have different, defined characteristics at the microRNA level, which might highlight a different originating tissue for the disease. From these results we have invesigated whole-genome g...
ORGANISM(S): Homo sapiens 
The gain-of-function mutation in the pleckstrin homology domain of AKT1 (AKT1E17K) occurs in lung and breast cancer. By use of human cellular models and of a AKT1E17K transgenic Cre-inducible murine strain (R26-AKT1E17K mice) we have demonstrated that AKT1E17K is a bona-fide oncogene for lung epithe...
ORGANISM(S): Mus musculus 
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