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TranscriptomicsmicroRNA and cancer progression in breast tumors
miRNAs are small non-coding RNAs frequently altered in human malignancies. They regulate protein-coding gene expression by mediating mRNA degradation and/or repressing translation via the association with the 3M-bM-^@M-^Y untranslated region (3M-bM-^@M-^Y UTR) of the mRNAs. Aberrant miRNA expression...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26659 | biostudies-arrayexpress
TranscriptomicsmiR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS and CSF1
Breast cancer is often fatal during its metastatic dissemination. To unravel the role of microRNAs (miRs) during malignancy, we analyzed miR expression in 77 primary breast carcinomas and identified 16 relapse-associated miRs that correlate with survival and/or distinguish tumor subtypes in differen...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26666 | biostudies-arrayexpress
TranscriptomicsmiR-148b modulates the expression of multiple genes
To identify which miR-148b targets were involved in tumorigenesis, a microarray analysis was performed for miR-148b over-expressing cells versus controls and 129 (49 up and 80 down) modulated genes were revealed. The effects of miR-148b on cancer progression depend on the direct and indirect regulat...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26662 | biostudies-arrayexpress
TranscriptomicsIdentification of the 3' end of the pig miRNA by the RAKE technology [platform 1: 9003467]
We applied a new computational approach to predict specie-specific and conserved miRNAs, than experimentally confirmed by a modified RNA-primed Array-based Klenow Extension (RAKE) method. We identified 489 conserved and 1,178 pig-specific novel miRNAs increasing our tally of confirmed miRNAs to 1,66...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-28137 | biostudies-arrayexpress
TranscriptomicsIdentification of the 3' end of the pig miRNA by the RAKE technology [platform 2: 9003179]
We applied a new computational approach to predict specie-specific and conserved miRNAs, than experimentally confirmed by a modified RNA-primed Array-based Klenow Extension (RAKE) method. We identified 489 conserved and 1,178 pig-specific novel miRNAs increasing our tally of confirmed miRNAs to 1,66...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-28138 | biostudies-arrayexpress
TranscriptomicsMessenger RNA transcript expression in the pig (S. scrofa)
90K Combimatrix gene expression microarrays were composed by 17,048 replicated probes and 963 not replicated specific for the Ensembl (Ver. 56) Transcripts (protein coding + pseudogenes + retrotransposed elements), 11,363 replicated probes specific for the UniGene clusters (Ver. 38) of length compri...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-27853 | biostudies-arrayexpress
TranscriptomicsIdentification of the 5' end of the pig miRNA by the RAKE technology
We applied a new computational approach to predict specie-specific and conserved miRNAs, than experimentally confirmed by a modified RNA-primed Array-based Klenow Extension (RAKE) method. We identified 489 conserved and 1,178 pig-specific novel miRNAs increasing our tally of confirmed miRNAs to 1,66...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-28139 | biostudies-arrayexpress
TranscriptomicsEvaluation of miRNA expression in 14 different tissues by the RAKE technology
The short length of miRNAs results in a high dynamic range of melting temperatures and therefore impedes a proper selection of detection probes or optimized PCR primers. While miRNA microarrays allow for massive parallel and accurate relative measurement of all known miRNAs, they have so far been le...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-28140 | biostudies-arrayexpress
TranscriptomicsIdentification of responsive probes for mRNA transcripts of the pig (S. scrofa) genome
Pig mRNAs Ensembl transcripts (Ver. 56) and UniGene (Ver. 38) sequences were used to produce a dedicated microarray platform to analyze mRNAs gene expression. Based on sequence similarity we rejected UniGene features that overlapped more than 40% with an Ensembl transcript. After this filter we obta...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-28636 | biostudies-arrayexpress
UnknownEnhanced recovery after bariatric surgery: a comprehensive survey-based analysis of ERABS actual clinical implementation in Italian bariatric centers.
Not available
S-EPMC12540566 | biostudies-literature
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