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UnknownA twin-sibling study on the relationship between exercise attitudes and exercise behavior.
Social cognitive models of health behavior propose that individual differences in leisure time exercise behavior are influenced by the attitudes towards exercise. At the same time, large scale twin-family studies show a significant influence of genetic factors on regular exercise behavior. This twin...
S-EPMC3893360 | biostudies-literature
UnknownAssociation of Serum Neurofilament Light Levels With Long-term Brain Atrophy in Patients With a First Multiple Sclerosis Episode.

Importance

Data are needed on the potential long-term prognostic association of serum neurofilament light in multiple sclerosis (MS).

Objective

To evaluate serum neurofilament light as a biomarker associated with long-term disease outcomes in clinically isolated syndrome.

Design, s...

S-EPMC7645699 | biostudies-literature
UnknownNeurofilament light levels are associated with long-term outcomes in multiple sclerosis.

Background

Neurofilament light chain (NfL) is a promising marker of disease activity/treatment response in multiple sclerosis (MS), although its predictive value for long-term clinical outcomes remains unclear.

Objective

We measured NfL from a phase 3 trial in relapsing-remitting MS a...
S-EPMC7604552 | biostudies-literature
UnknownEnteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity.
Mucosal barrier immunity is essential for the maintenance of the commensal microflora and combating invasive bacterial infection. Although immune and epithelial cells are thought to be the canonical orchestrators of this complex equilibrium, here, we show that the enteric nervous system (ENS) plays ...
S-EPMC7339937 | biostudies-literature
UnknownDaily intranasal palivizumab to prevent respiratory syncytial virus infection in healthy preterm infants: a phase 1/2b randomized placebo-controlled trial.

Background

Mucosal administration of monoclonal antibodies (mAbs) against respiratory pathogens is a promising alternative for systemic administration because lower doses are required for protection. Clinical development of mucosal mAbs is a highly active field yet clinical proof-of-concept ...
S-EPMC10772232 | biostudies-literature
UnknownMortality after surgery in Europe: a 7 day cohort study.

Background

Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfirmed. The European Surgical Outcomes Study was an...
S-EPMC3493988 | biostudies-literature
UnknownGenome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility.
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly genotyped) and 375,188 controls identified 54 significant (P < 5 × 10-8) loci with 68 independent single nucleotide polymor...
S-EPMC7255059 | biostudies-literature
UnknownGenome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults...
S-EPMC5407576 | biostudies-literature
UnknownCorrection: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
[This corrects the article DOI: 10.1371/journal.pgen.1006528.].
S-EPMC5567921 | biostudies-literature
UnknownNovel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs i...
S-EPMC6235897 | biostudies-literature
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