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ProteomicsProteomic profiling of MDC1A muscle using TMT quantitation, Bruno Oliveira
SUMMARY Congenital muscular dystrophy with laminin á2 chain-deficiency (MDC1A) is one of the most severe forms of muscular disease and is characterized by decreased muscle tone at birth, reduced movements and contractures. The genetic basis of MDC1A is well-known, yet the secondary mechanisms ultima...
ORGANISM(S): Mus musculus (Mouse) 
2014-07-08 | PXD000978 | Pride
Laminin α2 chain deficient muscle Metabolic alteration Extracellular matrix proteins Calcium dysregulation 
UnknownClassification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: A cross sectional observational study.

Background

Global brain health initiatives call for improving methods for the diagnosis of Alzheimer's disease (AD) and frontotemporal dementia (FTD) in underrepresented populations. However, diagnostic procedures in upper-middle-income countries (UMICs) and lower-middle income countries (LM...
S-EPMC9794191 | biostudies-literature
UnknownEvidence of whole-body vibration exercises on body composition changes in older individuals: a systematic review and meta-analysis.
Introduction: The aging process is associated with changes in body composition, including fat gain and skeletal muscle loss from middle age onward. Moreover, increased risk of functional decline and the development of chronic diseases are also related to aging. Objective: This systemat...
S-EPMC10652794 | biostudies-literature
TranscriptomicsHOXA9 transcriptomic analysis in GBM cell lines (U87MG, U251 and primary GBML18) and in immortalized human astrocytes (hTERT/E6/E7)
Assess gene expression patterns upon HOXA9 ectopic expression in U87MG GBM cell line and hTERT/E6/E7 immortalized human astrocytes, and HOXA9 silencing in U251 and GBML18 GBM cell lines. U87MG and hTERT/E6/E7 were retrovirally-infected with an MSCV control vector (MSCV-Control) or with a construct c...
ORGANISM(S): Homo sapiens 
2015-01-30 | E-GEOD-56517 | biostudies-arrayexpress
UnknownKetamine, Etomidate, and Mortality in Emergency Department Intubations.

Importance

The choice of induction agent during rapid sequence intubation (RSI) of critically ill adults may affect clinical outcomes. Although ketamine and etomidate are frequently used for RSI, their comparative effectiveness remains controversial.

Objective

To compare the safety of...
S-EPMC12706683 | biostudies-literature
UnknownMeasurement of the differential cross section for top quark pair production in pp collisions at [Formula: see text].
The normalized differential cross section for top quark pair ([Formula: see text]) production is measured in pp collisions at a centre-of-mass energy of 8[Formula: see text] at the CERN LHC using the CMS detector in data corresponding to an integrated luminosity of 19.7[Formula: see text]. The measu...
S-EPMC4657759 | biostudies-literature
ProteomicsCharacterization of the secretome of glial cells exposed to glioblastoma secreted factors
Glioblastoma (GBM), the most malignant primary brain tumor, is characterized by widespread heterogeneity, leading to poor and unpredictable clinical outcomes. Recent studies have provided evidences that the tumor microenvironment has a critical role in regulating tumor growth by establishing a compl...
ORGANISM(S): Mus musculus (Mouse) 
2017-10-09 | PXD006007 | Pride
Glial cells  gliobastome  secretome  swath-ms 
TranscriptomicsGene Expression Profile of AGS cell line cultured in 2D and in 3D conditions
AGS cell line was cultured in standard T25 flasks (2D condition) and in T25 flasks precoated with 50 M-5L/cm2 of matrigel basement membrane (BD Biosciences) at a 1.5:1 proportion to RPMI serum-free medium (3D condition, overlay method). Cultures were maintained for 14 days with medium change every t...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1234 | biostudies-arrayexpress
UnknownPeri-intubation adverse events and clinical outcomes in emergency department patients: the BARCO study.

Background

Emergency tracheal intubation in critically ill patients carries a high risk of complications, and practices vary substantially across different settings. Identifying risk factors and understanding how peri-intubation adverse events affect patient outcomes may guide standardizatio...
S-EPMC12007353 | biostudies-literature
UnknownHydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19.

Background

Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety and efficacy of these therapies is limited.

Methods

We conducted a multicenter, randomized, open-label, three-group, controlled tri...
S-EPMC7397242 | biostudies-literature
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