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TranscriptomicsThe Antarctic Krill Euphausia superba Shows Diurnal Cycles of Transcription under Natural Conditions.
BACKGROUND: Polar environments are characterized by extreme seasonal changes in day length, light intensity and spectrum, the extent of sea ice during the winter, and food availability. A key species of the Southern Ocean ecosystem, the Antarctic krill (Euphausia superba) has evolved rhythmic physio...
ORGANISM(S): Euphausia superba 
2013-07-23 | E-GEOD-42292 | biostudies-arrayexpress
TranscriptomicsInvolvement of miRNAs in the Regulation of Muscle Wasting during Catabolic Conditions.
Loss of muscle proteins and the consequent weakness has important clinical consequences in diseases such as cancer, diabetes, chronic heart failure and in ageing. In fact, excessive proteolysis causes cachexia, accelerates disease progression and worsens life expectancy. Muscle atrophy involves a co...
ORGANISM(S): Mus musculus 
2014-07-15 | E-GEOD-51648 | biostudies-arrayexpress
TranscriptomicsIdentification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells
Understanding transcriptional changes during cancer progression is of crucial importance to develop new and more efficacious diagnostic and therapeutic approaches. It is well known that ErbB2 is overexpressed in about 25% of human invasive breast cancers. We have previously demonstrated that p130Cas...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-42949 | biostudies-arrayexpress
TranscriptomicsFunctional characterization of a Drosophila melanogaster mitochondrial deoxynucleotide transporter dRIM2.
We have studied the deoxynucleotide transport in Drosophila melanogaster. On the basis of homology with the S. cerevisiae RIM2 gene, encoding a pyrimidine deoxynucleotide carrier (Marrobbio et al. 2006), the CG18317 gene (dRIM2) in the fruit fly may code for a deoxynucleotide carrier. We demonstrate...
ORGANISM(S): Drosophila melanogaster 
2014-05-02 | E-GEOD-48012 | biostudies-arrayexpress
TranscriptomicsmiR-148b modulates the expression of multiple genes
To identify which miR-148b targets were involved in tumorigenesis, a microarray analysis was performed for miR-148b over-expressing cells versus controls and 129 (49 up and 80 down) modulated genes were revealed. The effects of miR-148b on cancer progression depend on the direct and indirect regulat...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26662 | biostudies-arrayexpress
TranscriptomicsMessenger RNA transcript expression in the pig (S. scrofa)
90K Combimatrix gene expression microarrays were composed by 17,048 replicated probes and 963 not replicated specific for the Ensembl (Ver. 56) Transcripts (protein coding + pseudogenes + retrotransposed elements), 11,363 replicated probes specific for the UniGene clusters (Ver. 38) of length compri...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-27853 | biostudies-arrayexpress
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