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Proteomics“phyloquant” to study the evolutionary relationships of organisms based on large scale quantitative protein expression
“phyloquant” to study the evolutionary relationships of organisms based on large scale quantitative protein expression
ORGANISM(S): Trypanosoma cruzi Trypanosoma rangeli SC58 Trypanosoma erneyi Trypanosoma dionisii Trypanosoma cruzi marinkellei 
2021-09-09 | PXD017228 | Pride
Phyloquant 
ProteomicsLC-MS/MS - NS-NE - Zika Virus Impairs Neurogenesis and Synaptogenesis Pathways in Human Neural Stem Cells and Neurons
Growing evidences have associated Zika virus infection with congenital malformations, including microcephaly. Nonetheless, signaling mechanisms that promote the disease outcome are far from being understood, affecting the development of suitable therapeutics. In this study, we applied shotgun mass s...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD009293 | Pride
Lc-ms/ms 
ProteomicsCImP: Cellular Imprinting Proteomics applied to ocular disorders
A method (termed Cellular Imprinting Proteomics, CImP) for the identification and quantification of the ocular surface proteome using a minimally invasive membrane filter device is described. Moreover, The CImP method was applied to profile the molecular alterations in the eyes of infants exposed to...
ORGANISM(S): Homo sapiens (Human) 
2020-07-23 | PXD014038 | Pride
Cellular imprinting proteomic 
ProteomicsIdentification of astrocytomas through serum protein fingerprint using MALDI-TOF MS and machine learning
This study aimed to explore the potential of serum proteomics as a non-invasive diagnostic tool using MALDI-TOF mass spectrometry (MS) combined with machine learning techniques. We analyzed serum samples from 269 patients, employing machine learning models to differentiate between healthy individual...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD060922 | Pride
Maldi-tof ms Machine learning Glioblastoma 
ProteomicsSerum proteomics of infants in utero exposed to Zika virus without Congenital Zika Syndrome
In 2015, ZIKV infection attracted international attention during an epidemic in the Americas, when neurological disorders were reported in babies who had their mothers exposed to ZIKV during pregnancy. World Health Organization (WHO) epidemiological data show that 5 to 15% of neonates exposed to ZIK...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020294 | Pride
Zika virus Czs Serum 
ProteomicsSERUM PROTEOMICS OF Experimental MALARIA-associated ARDS REVEALS A REGULATION OF ACUTE PHASE RESPONSE PROTEINS
Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria-infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammatio...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-13 | PXD050496 | Pride
Biomarkers Malaria Acute resipratory distress syndrome Proteomics 
TranscriptomicsComparison of gene expression profiles of effector T cells from leptin-receptor-deficient mice and wild type mice
We have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed during leptin receptor deficiency, which is partly responsible for the inhibition of T cell effector functions. Mouse CD4+CD25- T cells were purified from leptin-receptor-...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-29607 | biostudies-arrayexpress
UnknownEfficacy of n-3 polyunsaturated fatty acids and feasibility of optimizing preventive strategies in patients at high cardiovascular risk: rationale, design and baseline characteristics of the Rischio and Prevenzione study, a large randomised trial in general practice.
Not available
S-EPMC2909229 | biostudies-literature
TranscriptomicsGene expression profiles of effector T cells induced by mTOR inhibition
To further develop our gene expression approach to treatment of autoimmunity, we have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed upon immunosuppressor treatment responsible for inhibition of T cell effector functions. Huma...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-29606 | biostudies-arrayexpress
ProteomicsDevelopment of a Trypanosoma cruzi Strain Typing Assay using MS2 peptide spectral libraries (Tc-STAMS2)
Chagas disease is one of the most important neglected diseases with an estimated number of 12 million infected individuals, the majority living in Central and South America. The Trypanosoma cruzi (T.cruzi) protozoan parasite is the etiological agent of Chagas disease. T.cruzi is highly genetically d...
ORGANISM(S): Trypanosoma cruzi 
2018-03-19 | PXD008088 | Pride
Trypanosoma cruzi  discrete typing units (dtus)  mass spectrometry  spectral matching  strain typing methods 
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