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MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
UnknownCIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative.
CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedica...
S-EPMC9305285 | biostudies-literature
TranscriptomicsIn vivo disruption of Rb-E2F-Ezh2 signaling loop causes bladder cancer development
Bladder cancer (BC) is a highly prevalent human disease in which Rb pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here we show that the in vivo inactivation of all Rb family genes in the mouse urothe...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-38264 | biostudies-arrayexpress
UnknownCharacteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain.

Objectives

To analyse the characteristics and predictors of death in hospitalized patients with coronavirus disease 2019 (COVID-19) in Spain.

Methods

A retrospective observational study was performed of the first consecutive patients hospitalized with COVID-19 confirmed by real-time P...
S-EPMC7399713 | biostudies-literature
UnknownKetamine, Etomidate, and Mortality in Emergency Department Intubations.

Importance

The choice of induction agent during rapid sequence intubation (RSI) of critically ill adults may affect clinical outcomes. Although ketamine and etomidate are frequently used for RSI, their comparative effectiveness remains controversial.

Objective

To compare the safety of...
S-EPMC12706683 | biostudies-literature
UnknownNoninvasive Ventilation for Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study.

Objectives

The worldwide practice and impact of noninvasive ventilation (NIV) in pediatric acute respiratory distress syndrome (PARDS) is unknown. We sought to describe NIV use and associated clinical outcomes in PARDS.

Design

Planned ancillary study to the 2016/2017 prospective Pedia...
S-EPMC10524424 | biostudies-literature
UnknownThe database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project.
The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of ...
S-EPMC5215197 | biostudies-literature
UnknownA multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.
The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regul...
S-EPMC8742248 | biostudies-literature
UnknownStatus of Sepsis Care in European Hospitals: Results from an International Cross-Sectional Survey.
Rationale: Early detection, standardized therapy, adequate infrastructure, and strategies for quality improvement should constitute essential components of every hospital's sepsis plan. Objectives: To investigate the extent to which recommendations from the sepsis guidelines are implem...
S-EPMC12005017 | biostudies-literature
UnknownEffect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.

Importance

The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.

Objective

To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19.

Design, setting, and participants

The ongoing...
S-EPMC8491132 | biostudies-literature
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