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TranscriptomicsGene expression profiling of peripheral blood mononuclear cells before and after eradication of Hepatitis C virus by DAAs
Remarkable improvements in the treatment of HCV infection have been observed since the availability of HCV Direct-antiviral agents (DAAs). We evaluated by microarray the transcriptomic profile of circulating mononuclear cells from 8 chronic HCV patients at baseline and 12 weeks after the end of 4 w...
ORGANISM(S): Homo sapiens 
2023-07-31 | E-MTAB-10952 | biostudies-arrayexpress
TranscriptomicsChronic lymphocytic leukemia cells are activated and proliferate in response to specific Th cells
Changes in gene expression profile of CLL cells in response to an antigen-specific Th cell clone that is specific for a Ckappa peptide of mouse Abs. Mouse anti human BCR mAbs were used to ligate BCR and deliver antigen to CLL cells. 32-45 x10e6 PBMC were incubated overnight with or without 2 μg/ml o...
ORGANISM(S): Homo sapiens 
2013-08-08 | E-GEOD-48268 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human patients with chronic kidney disease
Several reports have focused on the identification of biological elements involved in the development of abnormal systemic biochemical alterations in chronic kidney disease, but this abundant literature results most of the time fragmented. To better define the cellular machinery associated to this c...
ORGANISM(S): Homo sapiens 
2009-12-04 | E-GEOD-15072 | biostudies-arrayexpress
TranscriptomicsSodium arsenite induced gene expression changes in A549 human epithelial lung carcinoma cells
Arsenic is methylated during its metabolism, thereby depleting the intracellular methyl donor S-adenosyl-methionine, which may lead to disturbances in DNA methylation patterns which could lead to altered gene expression Cells were exposed to sodium arsenite (NaAsO2, Sigma) at concentrations of 0.08 ...
ORGANISM(S): Homo sapiens 
2014-09-17 | E-GEOD-44169 | biostudies-arrayexpress
TranscriptomicsIL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes are differentially expressed in CD4+ T cells of HTLV-1-infected individuals.
HTLV-1 preferentially infects CD4+ T cells and these cells play a central role in HTLV-1 infection. In this study, we investigated the global gene expression profile of circulating CD4+ T cells from distinct clinical status of HTLV-1-infected individuals in regard to Tax expression levels. CD4+ T ce...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-38537 | biostudies-arrayexpress
TranscriptomicsSodium arsenite induced changes in A549 human epithelial lung carcinoma cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-09-17 | E-GEOD-44174 | biostudies-arrayexpress
TranscriptomicsMajor Depressive Disorder blood gene expression
Background: Major Depressive Disorder (MDD) is a moderately heritable disorder with a high lifetime prevalence. At present, laboratory blood tests to support MDD diagnosis are not available. Methods: We used a classifier approach on blood gene expression profiles of a unique set of non-medicated su...
ORGANISM(S): Homo sapiens 
2011-10-04 | E-GEOD-19738 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of blasts from three APL patients expressing PML/RAR before and after treatment with 1 uM retinoic acid (RA) in vitro for four hours
Gene expression profiles in blasts from three APL patients expressing PML/RAR were assessed before and after treatment with 1 uM retinoic acid (RA) in vitro for four hours. We then studied a U937 clone conditionally expressing PML/RAR (U937-PR), (Grignani et al. 1993) (Alcalay et al. 2003), and comp...
ORGANISM(S): Homo sapiens 
2004-12-31 | E-MEXP-149 | biostudies-arrayexpress
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