Sort   by:  
 Page size 
SOXF transcription factors are highly relevant for endothelial biology, yet comprehensive binding data of the endogenous proteins in endothelial cells has not previously been published. We used CUT&RUN to determine the binding patterns of endogenous SOX7 and SOX17 in baseline human umbilical vein en...
ORGANISM(S): Homo sapiens 
SPOC1 is a chromatin affiliated protein with a functional role in stem cell differentiation, cell division, DNA damage response and higher order chromatin organization. To gain insight into SPOC1’s ability to modulate these processes, we elucidated the mechanisms targeting SPOC1 to chromatin and its...
ORGANISM(S): Mus musculus 
Repair of DNA Double Strand Breaks produced in transcriptionally active chromatin occurs through a mechanism, Transcription-Coupled DSB repair (TC-DSBR), that is yet poorly characterized. Here, using a screening approach scoring multiple outputs in human cells, we identified the PER complex, a key m...
ORGANISM(S): Homo sapiens 
The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target-selection and gene activation in each context. To investigate, we partitioned Drosophila chromatin into different states, based on histone modifications, es...
ORGANISM(S): Drosophila melanogaster 
Sort   by:  
 Page size