De novo protein design

Show results for

Unknown (1002)
Genomics (678)
Transcriptomics (90)
Proteomics (44)
Metabolomics (9)
Models (4)

Organisms

Homo sapiens (58)
Mus musculus (29)
Arabidopsis thaliana (5)
Escherichia coli (4)
Rattus norvegicus (3)
Danio rerio (3)
Saccharomyces cerevisiae (3)
Drosophila melanogaster (2)
Tettigonia cantans (2)
Aplysina aerophoba (1)
Hippoglossoides platessoides (1)
Eutrema salsugineum (1)
Puccinia striiformis f. sp. tritici 08/21 (1)
Porphyromonas gingivalis ATCC 33277 (1)
Helicoverpa zea (1)
Pimephales promelas (1)
Capsicum annuum (1)
Anguilla anguilla (1)
Mytilus edulis (1)
Dysidea avara (1)
Podospora anserina (1)
Nicotiana benthamiana (1)
synthetic construct (1)
Xenopus laevis (1)
mixed sample (1)
Staphylococcus aureus (1)
Sus scrofa (1)
Escherichia coli BL21(DE3) (1)
Arvicola (1)
Candidatus Endoriftia persephonae (1)

Organisms

Homo sapiens (285)
Mus musculus (171)
Arabidopsis thaliana (36)
Saccharomyces cerevisiae (14)
Caenorhabditis elegans (9)
Schizosaccharomyces pombe (8)
Rattus norvegicus (7)
Escherichia coli str. K-12 substr. MG1655 (6)
Drosophila melanogaster (6)
Danio rerio (5)
Tetrahymena thermophila (4)
Colletotrichum higginsianum IMI 349063 (3)
Phytophthora cinnamomi (3)
Plasmodium falciparum Dd2 (2)
Cunninghamia lanceolata (2)
synthetic construct (2)
Oryza rufipogon (2)
Xenopus laevis (2)
Glycine max (2)
Gallus gallus (2)
Escherichia coli (2)
Lilium maculatum (1)
Hemerocallis lilioasphodelus (1)
Bolitoglossa vallecula (1)
Solenopsis japonica (1)
Hakea prostrata (1)
Xenopus allofraseri (1)
Citrus jambhiri (1)
Eulophia maculata (1)
Phrynocephalus vlangalii (1)

Repository

ENA (673)
biostudies-arrayexpress (84)
pride (39)
geo (10)
MetaboLights (9)
BioModels (4)
EGA (2)
iProX (2)
MassIVE (1)
PanoramaPublic (1)

Tissue

Cell culture (5)
Epithelial cell (4)
B cell (2)
Integument (2)
Leaf (2)
Liver (2)
Blood cell (1)
Blood serum (1)
Dendritic cell (1)
Diploid cell (1)
Embryonic stem cell (1)
Endosperm (1)
HeLa cell (1)
Heart (1)
Hepatocyte (1)
Kidney (1)
Macrophage (1)
Permanent cell line cell (1)
Plant cell (1)
T cell (1)
Urine (1)

Disease

Breast cancer (3)
Ovarian cancer (1)
Normal (1)
Cervix carcinoma (1)
Disease free (1)
Hepatocellular carcinoma (1)
Oropharynx cancer (1)
Parasitic protozoa infectious disease (1)
Pharynx squamous cell carcinoma (1)
Tonsil squamous cell carcinoma (1)
Tuberculosis (1)

Technology Type

Mass Spectrometry (39)
Shotgun proteomics (14)
Mass spectrometry (7)
Bottom-up proteomics (7)
Data-dependent acquisition (4)
Gel-based experiment (3)
Mass spectrometry assay (2)
Chemical cross-linking coupled with mass spectrometry proteomics (2)
Data-independent acquisition (2)
SWATH MS (2)
Top-down proteomics (2)
Illumina HiSeq 2500, ILLUMINA (1)
Affinity purification coupled with mass spectrometry proteomics (1)
DiaPASEF (1)
HDMSE (1)
Immunopeptidomics (1)
MSE (1)
SRM/MRM (1)

Instrument Platform

Gas Chromatography MS - positive (3)
Liquid Chromatography MS - positive - reverse phase (3)
Illumina HiSeq 2500 (2)
Illumina NovaSeq 6000 (2)
TruSeq RNA Sample Preparation protocol (1)
Illumina HiSeq 4000 (1)
NextSeq 500 (1)
Q Exactive Plus (1)
Direct Infusion MS - Alternating (DI-MS (Alternating)) (1)
Gas Chromatography MS - (1)
Liquid Chromatography MS - (1)
Liquid Chromatography MS - Positive (LC-MS (Positive)) (1)
Liquid Chromatography MS - alternating - hilic (1)
Liquid Chromatography MS - negative - reverse phase (1)

Publication Date

2008 (25)
2025 (17)
2024 (14)
2009 (14)
2026 (12)
2022 (9)
2015 (8)
2014 (7)
2007 (6)
2016 (5)
2010 (5)
2023 (4)
2013 (4)
2020 (3)
2018 (3)
2012 (3)
2021 (3)
2019 (3)
2017 (2)
2011 (2)
2006 (1)

CHEBI ID

CHEBI:141588 (2)
CHEBI:15354 (2)
CHEBI:15428 (2)
CHEBI:15741 (2)
CHEBI:15756 (2)
CHEBI:15978 (2)
CHEBI:16113 (2)
CHEBI:16196 (2)
CHEBI:16467 (2)
CHEBI:16540 (2)
CHEBI:16865 (2)
CHEBI:16958 (2)
CHEBI:17015 (2)
CHEBI:17270 (2)
CHEBI:17351 (2)
CHEBI:17596 (2)
CHEBI:17797 (2)
CHEBI:18237 (2)
CHEBI:18257 (2)
CHEBI:25094 (2)
CHEBI:29864 (2)
CHEBI:30831 (2)
CHEBI:32154 (2)
CHEBI:33508 (2)
CHEBI:340824 (2)
CHEBI:36313 (2)
CHEBI:6650 (2)
CHEBI:71466 (2)
CHEBI:73990 (2)
CHEBI:75342 (2)

Metabolite Name

L-Arginine (2)
Linoleic acid (2)
Malic acid (2)
Oleamide (2)
Succinic acid (2)
(+)-(3,3''-bi-4H-1-benzopyran)-4,4''-dione,2,2'',3,3''-tetrahydro-5,5'',7''-trihydroxy-7-methoxy-2-(4-methoxyphenyl)-2''-(4-hydroxyphenyl) (1)
(+)-Medioresinol (1)
(+)-zuonin A (1)
(+-)-9-(2-Cyanoethyl)dihydrozeatin (1)
(+/-)-oxiran-2-ylmethyl (9Z)-hexadec-9-enoate (1)
(-)-Amurensisin (1)
(-)-Epicatechin(4.beta.-->8)(-)-epigallocatechin (1)
(-)-yatein (1)
(1-methyl-5-nitroimidazol-2-yl)methyl N-[1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]carbamate (1)
(10S,13R,14R,16R,17R)-16-hydroxy-17-[(2R)-1-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,13,14-pentamethyl-1,2,5,6,7,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-3-one (1)
(1E)-1-[2,2,4-trimethyl-3-[(1E,3E,5E,7E,9E)-3,7,12-trimethyltrideca-1,3,5,7,9,11-hexaenyl]cyclohex-3-en-1-ylidene]propan-2-one (1)
(1E,3E,5E,7E,9E,11E,13E,15Z)-1-[(2R,4S)-2,4-dihydroxy-2,6,6-trimethylcyclohexylidene]-16-(hydroxymethyl)-18-[(4R)-4-hydroxy-2,6,6-trimethylcyclohexen-1-yl]-3,7,12-trimethyloctadeca-3,5,7,9,11,13,15-heptaen-17-yn-2-one (1)
(1E,4E)-1-(3,4-dimethoxyphenyl)-5-(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one (1)
(1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(2-hydroxyphenyl)hepta-1,6-diene-3,5-dione (1)
(1R)-3,5,5-trimethyl-4-[(3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethylcyclohexen-1-yl)octadeca-3,5,7,9,11,13,15,17-octaen-1-ynyl]cyclohex-3-en-1-ol (1)
(1R,2R,3S,4S)-4-(2-hydroxyethyl)-2,3-bis(phenylmethoxymethyl)cyclopentan-1-ol (1)
(1R,2R,4S,4aS,6aS,6aS,6bR,12aS,14bS)-1,4,11-trihydroxy-1,2,6a,6b,9,12a-hexamethyl-10-oxo-2,3,4,5,6,6a,7,8,13,14b-decahydropicene-4a-carboxylic acid (1)
(1R,2R,4aS,6aR,6aS,6bR,8R,8aR,10S,12aR,14bS)-1,8,10-trihydroxy-1,2,6a,6b,12a-pentamethyl-9-methylidene-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid (1)
(1R,2R,4aS,6aR,6aS,6bR,8aR,10S,11R,12aR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,12a-pentamethyl-9-methylidene-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid (1)
(1R,2S,4S,4aS,8aS)-4a,8,8-trimethyl-1,2,3,4,5,6,7,8a-octahydronaphthalene-1,2,4-triol (1)
(1R,3R,4S,5R)-1,3,4-trihydroxy-5-[(E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]oxycyclohexane-1-carboxylic acid (1)
(1R,3aS,4E,7aR)-4-[2-[(3R,5R)-3,5-dimethyl-4-methylidenecyclohexylidene]ethylidene]-7a-methyl-1-[(E,2S)-6-methylhept-3-en-2-yl]-2,3,3a,5,6,7-hexahydro-1H-indene (1)
(1R,3aS,5aR,5bR,7aR,11aR,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-9-oxo-1-prop-1-en-2-yl-2,3,4,5,6,7,7a,11b,12,13,13a,13b-dodecahydro-1H-cyclopenta[a]chrysene-3a-carbaldehyde (1)
(1R,3aS,5aS,5bR,7aR,11aR,11bR,13aR,13bR)-5b,8,8,11a-tetramethyl-7,9-dioxo-1-prop-1-en-2-yl-1,2,3,4,5,6,7a,10,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysene-3a,5a-dicarboxylic acid (1)
(1R,4R,7R,8R,10R,13R,14S)-13,14-diethyl-7-[(3R,4S,6R)-3-hydroxy-4,6-dimethyloxan-2-yl]oxy-4,6,6,8,10-pentamethyl-17-[4-(4-pyridin-4-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone (1)

First Public Date

2025 (92)
2024 (70)
2023 (67)
2022 (67)
2014 (67)
2019 (51)
2020 (48)
2021 (44)
2017 (33)
2013 (32)
2026 (30)
2018 (29)
2016 (25)
2015 (18)

Modelling Approach

Computational model (4)

Lab affiliation

Laboratory of Molecular Instruments for Neurobiology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia (2)
-Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht -Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, Utrecht 3584 CH, Netherlands. -Netherlands Proteomics Center, Padualaan 8, Utrecht 3584 CH, Netherlands. (1)
1 Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, P.O.Box 263, FI-00029 HUS, Helsinki, Finland 2 Department of Biosciences and Nutrition, Karolinska Institutet, SE-171 76, Stockholm, Sweden. 3 Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. (1)
Associate Professor and Head-Proteomics Research, School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri Campus, Clappana P.O, Kollam - 690525 Kerala, India, Phone-0476-2803119, 2803110 (1)
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland (1)
Biozentrum Basel, University of Basel, Basel, Switzerland (1)
CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019, UMR 8204, CIIL – Centre d’Infection et d’Immunité de Lille, Univ. Lille, 59000 Lille, France (1)
Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QR UK (1)
Center for Genomic Regulation (CRG) (1)
Chemical Proteomics, Division of Chemistry I, MBB Dept., Biomedicum, Karolinska Insitute, Stockholm, Sweden (1)
Computational Mass Spectrometry & Proteomics Group Carlos Chagas Institute, Fiocruz - PR Brazil (1)
Department of Biochemistry, University of Washington, Seattle, WA, USA. Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA Institute for Protein Design, University of Washington, Seattle, WA, USA (1)
Department of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States. (1)
Department of Geoscience, University of Calgary, Calgary, AB, Canada; Department of Plant and Microbial Biology, North Carolina State University, Raleigh, North Carolina, USA (1)
Department of Medicine and General Service of Cytometry, Cancer Research Centre-IBMCC, IBSAL. University of Salamanca-CSIC, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain (1)
Department of Pediatric Oncology, Hematology, Immunology and Pulmonology University Medical Center for Children and Adolescents Im Neuenheimer Feld 430 D-69120 Heidelberg Germany ( lab head ) (1)
Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Center for Synthetic Biology, Northwestern University, Evanston, IL, USA (1)
Drug Discovery Moffitt Cancer Center Tampa, FL, USA (1)
Fred Hutchinson Cancer Research Center (1)
Genecology Research Centre, University of the Sunshine Coast (1)
Institut Jacques Monod (1)
Jiangnan university (1)
Karolinska Institutet, Stockholm, Sweden (1)
Key Laboratory of Ministry of Education for Genetic Improvement and Comprehensive Utilization of Crops, Fujian Provincial Key Laboratory of Crop Breeding by Design, College of Agriculture, Fujian Agriculture and Forestry University (1)
Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Netherlands (1)
Laboratory of Organic Mass Spectrometry, Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125, Catania, Italy (1)
Life Sciences Institute, Zhejiang University, Hangzhou 310058, China (1)
MRC Protein Phosphorylation and Ubiquitylation Unit, Faculty of Life Sciences, University of Dundee, UK (1)
Massachusetts Institute of Technology, Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine (1)
Medical Research Council - Laboratory of molecular biology (1)

IsPrivate

False (4)

Submitter Keywords

Ersilia (4)
FAIR-AIML (4)
Machine Learning Model (4)

Classification

bacteria (9)
protozoa (4)
fungi (1)

Modification

2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (55)
RNA-seq of coding RNA (8)
Comparative genomic hybridization by array (6)
Unknown experiment type (4)
RNAi profiling by array (2)
Genotyping by array (2)
Methylation profiling by high throughput sequencing (2)
ChIP-chip by tiling array (1)
Antigen profiling (1)
ATAC-seq (1)
ChIP-seq (1)
RNA-seq of non coding RNA (1)

Release Date

2025 (130)
2023 (116)
2024 (107)
2022 (102)
2021 (86)
2020 (80)
2018 (54)
2016 (45)
2014 (45)
2019 (39)
2017 (37)
2008 (36)
2015 (33)
2013 (33)
2009 (26)
2011 (24)
2012 (22)
2010 (18)
2026 (17)
2007 (16)
2003 (5)
2006 (4)
2004 (3)
2005 (2)
2001 (2)
2000 (2)
1999 (1)
1998 (1)

Previous page
1 / 183
You're on page 1
page 2
page 3
page 4
page 5
page ...
page 183
Next page

Sort by:

Relevance

Page size

A lipidomic human population and translational feeding study of hepatic steatosis and de novo lipogenesis (Human plasma assay)

Background: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Our aims were to investigate whether a sub-set of TAGs were as...

2018-03-13 | MTBLS616 | MetaboLights

A lipidomic human population and translational feeding study of hepatic steatosis and de novo lipogenesis (Murine liver assay)

2018-03-12 | MTBLS614 | MetaboLights

De Novo Design of Tyrosine and Serine Kinase Driven Protein Switches

: Kinases play central roles in signaling cascades, relaying information from the outside to the inside of mammalian cells1. De novo designed protein switches capable of interfacing with tyrosine kinase signaling pathways would open new avenues for controlling cellular behavior, but to date no su...

ORGANISM(S): Homo sapiens (Human)

2022-04-04 | PXD027295 | Pride