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MetabolomicsA metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance
Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe a...
2024-10-25 | MTBLS10416 | MetaboLights
MetabolomicsA homeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes ...

2024-01-09 | MTBLS7118 | MetaboLights
MetabolomicsUntargeted extraction of metabolites 13C labeling profiles from time course labeling switch experiment
Dynamic isotope labeling data provide crucial information about the operation of metabolic pathways, and are commonly generated via liquid chromatography mass spectrometry (LC-MS). Metabolome-wide analysis is challenging as it requires grouping of metabolite features over different samples. We devel...
2015-10-19 | MTBLS229 | MetaboLights
MetabolomicsSingle cell lipidomics of adherent gut epithelial cell lines Caco2 and HT29-MTX reveals a metabolic switch

Raw MS data files for the CaCo02 and HT29-MTX single cells isolated using the Yokogawa SS2000 for the research article 'Single cell lipidomics of adherent gut epithelial cell lines Caco2 and HT29-MTX reveals a metabolic switch' 

2026-03-18 | MTBLS14074 | MetaboLights
MetabolomicsInduction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer

Tumor-initiating cells (TICs) tend to reside in poorly vascularized regions of tumors and are subjected to nutrient stress. How TICs activate metabolic plasticity for adapting to periods of low nutrient availability, especially during glucose-limiting conditions, has remained unclarified. Here, w...

2025-09-29 | MTBLS8430 | MetaboLights
MetabolomicsUntargeted extraction of metabolites 13C labeling profiles from time course labeling switch experiment
Dynamic isotope labeling data provide crucial information about the operation of metabolic pathways, and are commonly generated via liquid chromatography mass spectrometry (LC-MS). Metabolome-wide analysis is challenging as it requires grouping of metabolite features over different samples. We devel...
2015-10-19 | MTBLS228 | MetaboLights
GenomicsPTIP promotes chromatin changes critical for immunoglobulin class switch recombination
Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here we show that activated B cells deficient in the PTIP component of the MLL3 (mix...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20852 | biostudies-arrayexpress
TranscriptomicsMechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch
Hypoxia-induced cell injury has been related to multiple pathological conditions. In order to render hypoxia-sensitive cells and tissues resistant to low O2 environment, in this current study, we used Drosophila melanogaster as a model to dissect the mechanisms underlying hypoxia-tolerance. A D. mel...
ORGANISM(S): Drosophila melanogaster 
2010-06-25 | E-GEOD-8803 | biostudies-arrayexpress
TranscriptomicsAn Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [AS microarray]
Alternative splicing (AS) is a key process underlying the expansion of proteomic diversity and the regulation of gene expression. However, the contribution of AS to the control of embryonic stem cell (ESC) pluripotency is not well understood. Here, we identify an evolutionarily conserved ESC-specifi...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-31948 | biostudies-arrayexpress
TranscriptomicsThe DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination
Class-switch recombination (CSR), induced by activation-induced cytidine deaminase, can be divided into two phases: DNA cleavage of the switch (S) regions, and the joining of the cleaved ends of the different S regions. Here, we show that the DSIF complex (Spt4 and Spt5), a transcription elongation ...
ORGANISM(S): Mus musculus 
2013-10-22 | E-GEOD-33206 | biostudies-arrayexpress
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