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ProteomicsMitochondrial interactome quantitation with dead-end peptides in failing murine heart
Dead-end peptide quantitation for improved interpretation of corresponding cross-link abundance differences
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD040864 | Pride
Mus musculus 
ProteomicsDEAD-box ATPase Dbp2 mediates mRNA release after 3’-end formation
mRNA biogenesis in the eukaryotic nucleus is a highly complex process. The numerous RNA processing steps are spatially and temporally coordinated to ensure that only fully processed transcripts are released into the nucleoplasm for export from the nucleus. Here, we explore the hypothesis that fissio...
ORGANISM(S): Schizosaccharomyces pombe 927 
2024-07-04 | PXD048560 | Pride
Dead-box atpase Rna processing Rnp remodelling Fission yeast Rna 3’ end formation Rna export Regulation of gene expression Sr protein 
UnknownIntegrated Analysis of Cross-Links and Dead-End Peptides for Enhanced Interpretation of Quantitative XL-MS.
Not available
S-EPMC10866149 | biostudies-literature
MetabolomicsProteolytic-Resistant Self-Assembling Peptide Nanofibers Combat Specific Bacterial Infections via Trap-and-Kill

The rise in global antibiotic resistance highlights the urgent need for effective antimicrobial agents. Antimicrobial peptides (AMPs) offer a potential solution to combat bacterial resistance. However, key challenges remain in addressing the limitations of current peptide drugs and biomaterials, ...

2025-06-13 | MTBLS12424 | MetaboLights
ProteomicsHeading towards a dead end: the role of DND1 in germ line differentiation of human iPSCs
The DND microRNA-mediated repression inhibitor 1 (DND1) is a conserved RNA binding protein (RBP) and plays an important role in survival and maintenance of primordial germ cells (PGCs) and the development of the male germline in zebrafish and mice. It was shown to be expressed in human pluripotent s...
ORGANISM(S): Homo sapiens (Human) 
2021-12-10 | PXD023802 | Pride
Primordial germ cells Proteomics Mass spectrometry Dnd1 Differentiation Human pluripotent stem cells 
TranscriptomicsTranscription profiling of human lymphocyte response to E. coli to identify any transcriptional component to the protection in vitro bacterially induced PBMC apoptosis
Sepsis induces lymphocyte apoptosis which can be prevented by over-expression of anti-apoptotic Bcl-2 family members. The anti-apoptotic activity of Bcl-2 family members is localized in the BH4 domain. The therapeutic peptide, TAT-BH4, was found to prevent sepsis-induced lymphocyte apoptosis in vi...
ORGANISM(S): Homo sapiens 
2006-02-07 | E-MEXP-555 | biostudies-arrayexpress
UnknownDevelopment of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexes.
Not available
S-EPMC3013449 | biostudies-literature
UnknownNitrodibenzofuran: A One- and Two-Photon Sensitive Protecting Group That Is Superior to Brominated Hydroxycoumarin for Thiol Caging in Peptides.
Not available
S-EPMC5026405 | biostudies-literature
ProteomicsSIM-XL: a powerful and user-friendly tool for peptide cross-linking analysis
Chemical cross-linking has emerged as a powerful approach for the structural characterization of proteins and protein complexes. However, the correct identification of covalently linked (cross-linked) peptides analyzed by tandem mass spectrometry is still an open challenge. Here we present SIM-XL, a...
ORGANISM(S): Homo sapiens (Human) 
2015-02-02 | PXD001677 | Pride
Cross-linked peptides Search engine Cross-linking 
ProteomicseXL-MS: An enhanced Cross-Linking Mass Spectrometry Workflow to Study Protein Complexes.
The analysis of proteins and protein complexes by cross-linking mass spectrometry (XL-MS) has expanded in the last dec-ade. However, mostly used approaches suffer important limitations in term of efficiency and sensitivity. We describe here a new workflow based on the advanced use of the trifunction...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2021-08-11 | PXD010422 | Pride
Creatine kinase Mass spectrometry Cross-link Monoavidin biotin affinty enrichment Click chemistry 
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