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TranscriptomicsThe Kinase SGK1 in the Endoderm and Mesoderm Promotes Ectodermal Survival by Downregulating Components of the Death-Inducing Signaling Complex
A balance between cell survival and apoptosis is essential for animal development. Although proper development involves multiple interactions between germ layers, little is known about the intercellular and intertissue signaling pathways that promote cell survival in neighboring or distant germ laye...
ORGANISM(S): Xenopus laevis 
2011-02-21 | E-GEOD-26381 | biostudies-arrayexpress
MetabolomicsMulti-Omics Approach to Elucidate Cerebrospinal Fluid Changes in Dogs with Intervertebral Disc Herniation
Herniation of the intervertebral disc (IVDH) is the most common cause of neurological and intervertebral disc degeneration-related diseases. Since the disc starts to degenerate before it can be observed by currently available diagnostic methods, there is an urgent need for novel diagnostic approache...
2021-11-04 | MTBLS2689 | MetaboLights
ModelsNeumann2010_CD95Stimulation_NFkB_Apoptosis
This is the reduced model (model 8) described in: Dynamics within the CD95 death-inducing signaling complex decide life and death of cells. Leo Neumann, Carina Pforr, Joel Beaudouin, Alexander Golks, Peter H. Krammer, Inna N. Lavrik and Roland Eils (German Cancer Research Center (DKF...
2024-09-02 | BIOMD0000000243 | BioModels
TranscriptomicsHuman annulus disc cells grown in a 3D collagen sponge and exposed to TNF-a
The objective of this study was to determine how TNF-a, an important proinflammatory cytokine, affects gene expression in the human annulus. Cells were grown in a 3D collagen construct for 14 days with TNF-a. mRNA was isolated and subjected to microarray. Fold changes in gene expression were determ...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-41883 | biostudies-arrayexpress
TranscriptomicsJAK/STAT coordinates cell proliferation during disc regeneration with Dilp8-mediated developmental delay in Drosophila melanogaster
Regeneration of fragmented Drosophila imaginal discs occurs in an epimorphic manner, involving local cell proliferation at the wound site. Following disc fragmentation, cells at the wound site activate a restoration program through wound healing, regenerative cell proliferation and repatterning of t...
ORGANISM(S): Drosophila melanogaster 
2015-04-10 | E-GEOD-54868 | biostudies-arrayexpress
TranscriptomicsDownregulation of miR-760 Causes Human Intervertebral Disc Degeneration by Targeting the MyD88/Nuclear Factor-Kappa B Signaling Pathway
Dysregulation of microRNAs (miRNAs) plays a critical role in the development of intervertebral disc degeneration (IDD). In this study, we present evidence from in vitro and in vivo research to elucidate the mechanism underlying the role of miR-760 in IDD. miRNA microarray and quantitative reverse tr...
ORGANISM(S): Homo sapiens 
2022-03-17 | E-MTAB-11554 | biostudies-arrayexpress
TranscriptomicsThe exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development
Wingless (Wg)/Wnt signaling is conserved in all metazoan animals and plays critical roles in development. The Wg/Wnt morphogen reception is essential for signal activation, whose activity is mediated through the receptor complex and a scaffold protein Dishevelled (Dsh). We report here that the exon ...
ORGANISM(S): Drosophila melanogaster 
2016-08-19 | E-GEOD-81220 | biostudies-arrayexpress
UnknownReconstruction of the Fas-Based Death-Inducing Signaling Complex (DISC) Using a Protein-Protein Docking Meta-Approach.
Not available
S-EPMC8389534 | biostudies-literature
UnknownAssembly and activation of the death-inducing signaling complex.
Not available
S-EPMC12168016 | biostudies-literature
UnknownPeroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase.
Not available
S-EPMC3132003 | biostudies-literature
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