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TranscriptomicsRNA-seq of human hTERT-RPE1 and RPE1-MYCN-ER cells with treatment of EtOH (0h) or tamoxifen for 24h, 48h and 72h to activate MYCN
RNA-seq upon MYCN activation in the hTERT-immortalized MYCN retinal pigmented epithelial cell line (RPE1–MYCN-ER). The parental hTERT-immortalized retinal pigment epithelium (hTERT-RPE1) was used as a control as this cell line does not carry the MYCN:ER expression construct. Both cell lines were tre...
ORGANISM(S): Homo sapiens 
2021-06-03 | E-MTAB-9667 | biostudies-arrayexpress
GenomicsChIP-seq of neuroblastoma IMR-32, CLB-GA, NGP, IMR-5/75, GI-M-EN, CHP-212, and IMR-5 cell lines to identify TBX2, MYCN, H3K27ac, H3K4me1 and H3K4me3 binding sites
ChIP-seq to define bindings sites for TBX2, MYCN, H3K27ac, H3K4me1, H3K4me3 and Input in the cell lines IMR-32, CLB-GA, NGP, IMR-5/75, GI-M-EN, CHP-212, and IMR-5.
ORGANISM(S): Homo sapiens 
2018-10-16 | E-MTAB-6570 | biostudies-arrayexpress
TranscriptomicsRNA-seq of IMR-5/75 neuroblastoma cell line treated with JQ1, THZ1 or combination against untreated controls
RNA-seq upon JQ1 (1 uM), THZ1 (35 nM), UT (untreated) or combination treatment in the neuroblastoma cell line IMR-5/75. Analysis was performed 10h upon treament. Four biological replicates per condition.
ORGANISM(S): Homo sapiens 
2018-08-17 | E-MTAB-7025 | biostudies-arrayexpress
TranscriptomicsATAC-seq in neuroblastoma IMR-32 cell line
ATAC-seq to define open chromatin in the neuroblastoma IMR-32 cell line.
ORGANISM(S): Homo sapiens 
2018-08-16 | E-MTAB-6562 | biostudies-arrayexpress
TranscriptomicsRNA-seq of CLB-GA neuroblastoma cell line upon TBX2 knockdown
RNA-seq upon TBX2 knockdown in the neuroblastoma cell line CLB-GA. Cells were transduced with two different shRNAs (sh#2 and sh#4) targeting TBX2 and a non-targeting control (NTC), and selected with puromycin. Analysis was performed seven days upon TBX2 knockdown, including three biological replicat...
ORGANISM(S): Homo sapiens 
2018-08-16 | E-MTAB-6567 | biostudies-arrayexpress
TranscriptomicsRNA-seq of IMR-5/75 neuroblastoma cell line upon TBX2 and/or MYCN knockdown
RNA-seq upon TBX2, MYCN or combination of TBX2 and MYCN knockdown in the neuroblastoma cell line IMR-5/75. Cells were transduced with two different shRNAs (shTBX2_2 and shTBX2_4) targeting TBX2 and a non-targeting control (NTC), and selected with puromycin. Cells were treated with doxycycline for sh...
ORGANISM(S): Homo sapiens 
2018-08-16 | E-MTAB-6568 | biostudies-arrayexpress
GenomicsSOX11 ChIP-seq in neuroblastoma cell line IMR-32
ChIP-seq to define bindings sites for SOX11 and Input in the neuroblastoma cell line IMR-32
ORGANISM(S): Homo sapiens 
2021-11-30 | E-MTAB-9464 | biostudies-arrayexpress
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