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TranscriptomicsRibosome profiling of early zebrafish embryos -- miRNA-mediated regulation during embryogenesis causes translational repression before mRNA decay
MicroRNAs regulate gene expression through deadenylation, repression and mRNA decay. However, the contribution of each mechanism in non-steady-state situations remains unclear. We monitored the impact of miR-430 on ribosome occupancy of endogenous mRNAs in wild type and dicer mutants lacking mature...
ORGANISM(S): Danio rerio 
2012-03-15 | E-GEOD-34743 | biostudies-arrayexpress
TranscriptomicsHeritable variation of mRNA decay rates in yeast
Gene expression levels are determined by the balance between rates of mRNA transcription and decay, and genetic variation in either of these processes can result in heritable differences in transcript abundance. Although the genetics of gene expression has been the subject of intense interest, the c...
ORGANISM(S): Saccharomyces cerevisiae 
2014-09-16 | E-GEOD-60617 | biostudies-arrayexpress
TranscriptomicsMeasurement of temperature affects on Arabidopsis transcription and decay rates
The goal of this study is to measure Arabidopsis mRNA transcription and mRNA decay rates genome wide at two temperatures, and thus to calculate the temperature coefficient of both processes. Sensing and response to ambient temperature is important for controlling growth and development of many organ...
ORGANISM(S): Arabidopsis thaliana 
2013-12-07 | E-GEOD-53071 | biostudies-arrayexpress
GenomicsExamination of mRNA decay rate in mature adipocytes
Examination of mRNA decay rate in mature adipocytes
PRJEB34552 | ENA
TranscriptomicsExamination of mRNA decay rate in mature adipocytes
The CCR4-NOT deadenylase complex has a critical function to trigger mRNA decay and various biological events. To understand roles of the complex in adipocyte function, we compare mRNA half-lives between control and Cnot complex-deficient mature adipocytes from iWAT and BAT.
ORGANISM(S): Mus musculus 
2019-10-24 | E-MTAB-8371 | biostudies-arrayexpress
TranscriptomicsExamination of mRNA decay rate in mouse embryonic fibroblasts
The CCR4-NOT dedadenylase complex is essential for mRNA decay and various biological events.To understand roles of the complex in mouse embryonic fibroblasts, we compared mRNA half-lives between control and Cnot complex-deficient mouse embryonic fibroblasts
ORGANISM(S): Mus musculus 
2020-01-29 | E-MTAB-8287 | biostudies-arrayexpress
GenomicsExamination of mRNA decay rate in mouse embryonic fibroblasts
Examination of mRNA decay rate in mouse embryonic fibroblasts
PRJEB34204 | ENA
TranscriptomicsPervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [RNA-Seq_2]
Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-78209 | biostudies-arrayexpress
GenomicsWood decay metagenome
Wood decay metagenome Metagenome
PRJNA550260 | ENA
TranscriptomicsGrowth-rate dependency of de novo resveratrol production in chemostat cultures of an engineered Saccharomyces cerevisiae strain
Saccharomyces cerevisiae has become a popular host for production of non-native compounds. The metabolic pathways involved generally require a net input of energy. To maximize the ATP yield on sugar in S. cerevisiae, industrial cultivation is typically performed in aerobic, sugar-limited fed-batch r...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-22 | E-GEOD-65942 | biostudies-arrayexpress
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