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GenomicsGenome wide mapping of NFAT1 binding sites in dendritic cells and of chromatin state in steady and dectin-1 activated dendritic cell line D1
We generated genome-wide chromatin-state maps of mouse dendritic cells in steady and dectin-1 activated with or without NFAT inhibitor FK506. We found the differential H3K4me3 signatures in these cells. This study provides the epigenetic signatures of steady, dectin-1activated with or without NFAT i...
ORGANISM(S): Mus musculus 
2015-01-05 | E-GEOD-59998 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of dectin-1 and NFAT responsive genes in dendritic cells
This study provides the dectin-1 and NFAT responsive genes for 2h and 4h of curdlan treatment. Affymetrix Mouse Gene 1.0ST Arrays were used to profile gene expression in curdlan-stimulated D1 cells (2h or 4h exposure) that had been treated or not with FK506 for the duration of culture. Dendritic cel...
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-59896 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse MyD88-deficient bone marrow-derived macrophages treated with Zymosan
Innate immune pattern recognition receptors play critical roles in pathogen detection and initiation of antimicrobial responses. We and others have previously demonstrated the importance of the beta-glucan receptor Dectin-1 in the recognition of pathogenic fungi by macrophages and dendritic cells, a...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6376 | biostudies-arrayexpress
TranscriptomicsDectin-1-mediated signaling leads to characteristic gene expressions in rat mast cells
Rat mast cell line RBL-2H3 was analyzed to investigate the molecular mechanism of Dectin-1-mediated activation and responses of mast cells. Dectin-1-mediated signaling stimulated characteristic gene expression, such as MCP-1, IL-4, IL-13, TNF-αand Nfkbiz. RBL-2H3 cell line stably expressing Dectin-1...
ORGANISM(S): Rattus norvegicus 
2014-03-27 | E-GEOD-56246 | biostudies-arrayexpress
GenomicsCandida albicans induces monocyte training via epigenetic programming through a dectin 1-dependent pathway
Non-specific protective effects against reinfection have been described following infection with Candida albicans. Here we show that mice defective in functional T and B lymphocytes were protected against reinfection with C. albicans in a monocyte-dependent manner. C. albicans and beta glucans induc...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-34260 | biostudies-arrayexpress
GenomicsDectin-1 Fc and Dectin-2 Fc
Dectin-1 Fc and Dectin-2 Fc Raw sequence reads
PRJNA1146185 | ENA
GenomicsEffect of Dectin-1 and Fcgr2b on IVIg mediated reprogramming of monocytes
Effect of Dectin-1 and Fcgr2b on IVIg mediated reprogramming of monocytes
PRJNA932448 | ENA
GenomicsGenome-wide analysis of the CARD9/Dectin-1 transcriptional program in neutrophils and macrophages by RNA-seq
Genome-wide analysis of the CARD9/Dectin-1 transcriptional program in neutrophils and macrophages by RNA-seq
PRJNA625958 | ENA
TranscriptomicsDectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity [human]
C-type lectin receptors (CLRs) are a large family of immunoreceptors that recognizes polysaccharides exposed on pathogens and triggers innate immune responses. However, the ligand spectrums of the whole members have not been fully understood. In this study, we found that seaweed-derived fucan activa...
ORGANISM(S): Homo sapiens 
2017-08-25 | GSE98814 | GEO
TranscriptomicsDectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity [mouse]
C-type lectin receptors (CLRs) are a large family of immunoreceptors that recognizes polysaccharides exposed on pathogens and triggers innate immune responses. However, the ligand spectrums of the whole members have not been fully understood. In this study, we found that seaweed-derived fucan activa...
ORGANISM(S): Mus musculus 
2017-08-25 | GSE98825 | GEO
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