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TranscriptomicsDOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs
Retinoic-acid receptor-related orphan receptor-γt-positive (RORγt+) innate lymphoid cells (ILCs) produce interleukin (IL)-22 and IL-17, which are critical for protective immunity against enteric pathogens. The molecular mechanism underlying the development and survival of RORγt+ ILCs is not thorough...
ORGANISM(S): Mus musculus 
2014-06-25 | E-GEOD-58765 | biostudies-arrayexpress
UnknownDedicator of cytokinesis 8 (DOCK8) mutation impairs the differentiation of helper T cells by regulating the glycolytic pathway of CD4+ T cells.
Not available
S-EPMC11424684 | biostudies-literature
UnknownLarge deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome.
Not available
S-EPMC2818862 | biostudies-literature
ProteomicsProteomics profiling to distinguish DOCK8 deficiency from atopic dermatitis
Background: DOCK8 deficiency is an autosomal recessive form of hyperimmunoglobulinemia E syndrome (HIES). Severe atopic dermatitis (AD) shares with DOCK8 deficiency some clinical symptoms, including eczema, eosinophilia, and increased serum IgE levels. The deficiency of DOCK8 protein is potentially ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-17 | PXD029052 | Pride
Atopic dermatitis Multiple-reaction monitoring Label-free proteomics Lc-mse synaptg2 Dedicator of cytokinesis (dock8) Hyper ige syndrome (hies) 
UnknownSomatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype.
Not available
S-EPMC4132167 | biostudies-literature
UnknownDedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities.
Not available
S-EPMC2245991 | biostudies-literature
UnknownThe extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency.
Not available
S-EPMC4530066 | biostudies-literature
UnknownHaploidentical Related Donor Hematopoietic Stem Cell Transplantation for Dedicator-of-Cytokinesis 8 Deficiency Using Post-Transplantation Cyclophosphamide.
Not available
S-EPMC5757872 | biostudies-literature
UnknownDedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation.
Not available
S-EPMC5099100 | biostudies-literature
UnknownHyper IgE Syndrome Associated With Warts: A First Case of Dedicator of Cytokinesis 8 Deficiency in the Philippines.
Not available
S-EPMC7673426 | biostudies-literature
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