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ProteomicsProfiling extra cellular matrix core proteome of human fetal nucleus pulposus in search for regenerative targets
Intervertebral disc degeneration is accompanied by a loss of Extra-cellular matrix (ECM) content due to an imbalance in anabolic and catabolic pathways. Identifying ECM proteins with anabolic and/or regenerative potential could be the key to developing regenerative therapies. Since human fetal discs...
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD021431 | Pride
Np Esi-lc-ms/ms Adult Human Fetus Regenerative potential. Ivd Degenerated discs 
TranscriptomicsThe long noncoding RNA expression profile of human intervertebral disc degeneration identified by microarray analysis
In addition to the well-known short noncoding RNAs as miRNAs, increasing evidence suggests that long noncoding RNAs (lncRNAs) act as key regulators in a wide aspect of biologic processes. Dysregulated expression of lncRNAs has been demonstrated being implicated in a variety of human diseases. Howeve...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-56081 | biostudies-arrayexpress
GenomicsTranscriptional profiling of human cartilage endplate cells identified novel genes and cell clusters underlying degenerated and non-degenerated phenotypes
Transcriptional profiling of human cartilage endplate cells identified novel genes and cell clusters underlying degenerated and non-degenerated phenotypes
PRJNA1011258 | ENA
UnknownRegenerative effects of platelet-rich plasma releasate injection in rabbit discs degenerated by intradiscal injection of condoliase.
Not available
S-EPMC10631205 | biostudies-literature
UnknownTranscriptomic and Functional Comparison of Cells Isolated From Healthy and Degenerated Ovine Intervertebral Discs.
Not available
S-EPMC12825213 | biostudies-literature
GenomicsTranscriptional profiling of human cartilage endplate cells identified novel genes and cell clusters underlying degenerated and non-degenerated phenotypes (scRNA-seq)
Transcriptional profiling of human cartilage endplate cells identified novel genes and cell clusters underlying degenerated and non-degenerated phenotypes (scRNA-seq)
PRJNA1013482 | ENA
TranscriptomicsTranscriptional profiling of human cartilage endplate cells identified novel genes and cell clusters underlying degenerated and non-degenerated phenotypes
Background: Low back pain is a leading cause of disability worldwide and is frequently attributed to intervertebral disc (IVD) degeneration. Though the contributions of the adjacent cartilage endplates (CEP) to IVD degeneration are well documented, the phenotype and functions of the resident CEP cel...
ORGANISM(S): Homo sapiens 
2024-01-10 | GSE242040 | GEO
TranscriptomicsTranscriptional profiling of human cartilage endplate cells identified novel genes and cell clusters underlying degenerated and non-degenerated phenotypes (scRNA-seq)
Background: Low back pain is a leading cause of disability worldwide and is frequently attributed to intervertebral disc (IVD) degeneration. Though the contributions of the adjacent cartilage endplates (CEP) to IVD degeneration are well documented, the phenotype and functions of the resident CEP cel...
ORGANISM(S): Homo sapiens 
2024-01-10 | GSE242443 | GEO
UnknownInjectable bioorthogonal hydrogel (BIOGEL) accelerates tissue regeneration in degenerated intervertebral discs.
Not available
S-EPMC9764133 | biostudies-literature
UnknownBone marrow mesenchymal stem cells combined with ultra-purified alginate gel as a regenerative therapeutic strategy after discectomy for degenerated intervertebral discs.
Not available
S-EPMC7057222 | biostudies-literature
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