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ProteomicsProfiling of retinaldehyde dehydrogenases in cancer cells
Retinaldehyde dehydrogenases convert retinal into all-trans retinoic acid (ATRA), thereby regulating cell differentiation and cancer stem cell proliferation. Chemical tools and methods are valuable commodities to study aldehyde dehydrogenase (ALDH) activity in human cells. Here, we describe the desi...
ORGANISM(S): Homo sapiens (Human) 
2019-12-18 | PXD015495 | Pride
Human Cancer Activity-based protein profiling Aldehyde dehydrogenases 
ProteomicsAcetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide
Histone modifying enzymes depend on the availability of cofactors, with acetyl-CoA being required for histone acetyltransferase (HAT) activity. The discovery that mitochondrial acyl-CoA producing enzymes are also delivered to the nucleus suggests that high concentrations of metabolites generated loc...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD040979 | Pride
Mediator  pyruvate dehydrogenase  2-ketoacid dehydrogenases  acetylation  chromatin  transcription 
TranscriptomicsRNAi knock down of Enigma, a mitochondrial protein with homology to acyl-CoA dehydrogenases, in Drosophila
5 day RNAi treatment to knockdown Enigma, CG9006, a Drosophila mitochondrial protein with homology to acyl-CoA dehydrogenases. Experiment Overall Design: Kc-167 cells, 5 day treatment with Enigma-specific RNAi or beta-lactamase control RNAi. Specifics:1.6X10^6 cells in 0.5mL of serum-free Sang's M3 ...
ORGANISM(S): Drosophila melanogaster 
2007-07-31 | E-GEOD-3566 | biostudies-arrayexpress
GenomicsAromatic dimer dehydrogenases from Novosphingobium aromaticivorans reduce aromatic diketones
Aromatic dimer dehydrogenases from Novosphingobium aromaticivorans reduce aromatic diketones
PRJNA731907 | ENA
TranscriptomicsAromatic dimer dehydrogenases from Novosphingobium aromaticivorans reduce aromatic diketones
Aromatic diketones are a major product of formic acid lignin depolymerization. Novosphingobium aromaticivorans can degrade these diketones, but the enzymes used in this process were unknown. We used RNA-Seq to identify aromatic dimer dehydrogenases as potential candidates for the initial reduction o...
ORGANISM(S): Novosphingobium aromaticivorans DSM 12444 
2021-05-22 | GSE174697 | GEO
ProteomicsAcetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide
Histone modifying enzymes depend on the availability of cofactors, with acetyl-CoA being required for lysine acetyltransferase (KAT) activity. The discovery that mitochondrial acyl-CoA producing enzymes are also delivered to the nucleus, suggests that high concentrations of metabolites generated loc...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-14 | PXD040937 | Pride
Histone post translational modifications 
Genomics
Aromatic dimer dehydrogenases
PRJNA732422 | ENA
GenomicsInosine monophosphate dehydrogenases are key players for functional embryo and seedling development in Arabidopsis
Inosine monophosphate dehydrogenases are key players for functional embryo and seedling development in Arabidopsis
PRJNA1374124 | ENA
GenomicsAcetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide [Chipseq_MED1_RAW2647]
Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide [Chipseq_MED1_RAW2647]
PRJNA1029018 | ENA
GenomicsAcetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide [Chipseq_FLAG_DLST_ODGH]
Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide [Chipseq_FLAG_DLST_ODGH]
PRJNA1028517 | ENA
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