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ProteomicsDEK/NUP214 SILAC interactormics analysis
Among most of leukemogenic fusion proteins the aberrant localization that the translocation partners are forced in when compared to their wt counterparts contributes to leukemogenesis most likely by a sequester of interaction partners. The aim was to disclose the role of localization of DEK/NUP214...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031885 | Pride
Silac Dek/nup214 Interactome 
GenomicsXPO1-dependency of DEK::NUP214 leukemia sensitizes against eltanexor
XPO1-dependency of DEK::NUP214 leukemia sensitizes against eltanexor
PRJNA1126303 | ENA
GenomicsXPO1-dependency of DEK::NUP214 leukemia sensitizes against eltanexor
We aimed to investigate the role of XPO1 in this rare leukemia subtype. ChIP-sequencing was performed for XPO1 and NUP214 (as surrogate for DEK::NUP214 protein), and found co-occupancy of both proteins in putative DEK::NUP214 target genes.
ORGANISM(S): Homo sapiens 
2025-03-28 | GSE270396 | GEO
UnknownDEK-NUP214-Fusion Identified by RNA-Sequencing of an Acute Myeloid Leukemia with t(9;12)(q34;q15).
Not available
S-EPMC6070322 | biostudies-literature
UnknownTransformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromised mouse model.
Not available
S-EPMC5064821 | biostudies-literature
TranscriptomicsGene expression changes induced by eltanexor in the FKH-1 cell line and PDX model
We aimed to investigate the role of XPO1 in this rare leukemia subtype. RNA-seq was performed in DEK::NUP214 expressing cell line in control and eltanexor-treated samples, an inhibitor of XPO1, to elucidate the genes and pathways involved in DEK::NUP214 AML
ORGANISM(S): Homo sapiens 
2025-03-28 | GSE270397 | GEO
TranscriptomicsGene regulation in t(6;9) AML resembles that of FLT3-ITD/NPM1 AML with an altered HOX/MEIS axis [RNA-seq]
Acute Myeloid Leukemia (AML) represents a heterogeneous group of hematological malignancies. The t(6;9)(p23;q34) translocation, giving rise to the DEK::NUP214 fusion protein, is a rare mutation which produces a highly aggressive AML associated with extremely poor prognosis. Here, we utilise genome-w...
ORGANISM(S): Homo sapiens 
2024-01-04 | GSE240267 | GEO
GenomicsGene regulation in t(6;9) AML resembles that of FLT3-ITD/NPM1 AML with an altered HOX/MEIS axis [DNase-hypersensitivity]
Acute Myeloid Leukemia (AML) represents a heterogeneous group of hematological malignancies. The t(6;9)(p23;q34) translocation, giving rise to the DEK::NUP214 fusion protein, is a rare mutation which produces a highly aggressive AML associated with extremely poor prognosis. Here, we utilise genome-w...
ORGANISM(S): Homo sapiens 
2024-01-04 | GSE240268 | GEO
UnknownTargeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements.
Not available
S-EPMC7486696 | biostudies-literature
UnknownUnderstanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation.
Not available
S-EPMC9639852 | biostudies-literature
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