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ProteomicsRAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR
Uveal melanoma (UM) is a high fatality cancer. It arises in the eye and spreads (metastasizes) to the liver in 50% of affected patients, with a low survival rate of 5 years. In >85% of patients, their ocular tumors have mutations in specific genes, GNAQ and GNA11, leading to tumor progression and me...
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD068873 | Pride
Uveal melanoma Liver metastasis. Mnk1/2 Rab1a Mtor 
ProteomicsHuman Uveal Melanome-surfaceome
A quantitative surface biotin-labeling approach combined with mass spectrometry was used to identify differentially expressed surface proteins in uveal melanoma (UM) cells, in which RAB1A was either knocked down or overexpressed, compared with the respective controls.
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD069080 | Pride
Uveal melanome Surface proteome 
UnknownColombian surgical outcomes study insights on perioperative mortality rate, a main indicator of the lancet commission on global surgery - a prospective cohort study.
Not available
S-EPMC11382124 | biostudies-literature
ProteomicsA non-hazardous deparaffinization protocol enables quantita-tive proteomics of core needle biopsy-sized formalin-fixed and paraffin embedded (FFPE) tissue specimens.
Most human tumor tissues that are obtained for pathology and diagnostic purposes are forma-lin-fixed and paraffin embedded (FFPE). To perform quantitative proteomics of FFPE samples, paraffin has to be removed and formalin-induced crosslinks have to be reversed prior to prote-olytic digestion. A c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD031946 | Pride
Clinical proteomics  tumor tissues  ffpe  quantitative proteomics  core needle biopsy  cancer research  molecular pathology  breast ductal carcinoma  in-situ cancer 
UnknownMNK2 governs the macrophage antiinflammatory phenotype.
Not available
S-EPMC7959504 | biostudies-literature
UnknownEarly short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis.
Not available
S-EPMC9112652 | biostudies-literature
UnknownHandling of the Covid-19 Pandemic and Its Effects on Bariatric Surgical Practice: Analysis of GENEVA Study Database.
Not available
S-EPMC9592878 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
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