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ProteomicsRAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR
Uveal melanoma (UM) is a high fatality cancer. It arises in the eye and spreads (metastasizes) to the liver in 50% of affected patients, with a low survival rate of 5 years. In >85% of patients, their ocular tumors have mutations in specific genes, GNAQ and GNA11, leading to tumor progression and me...
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD068873 | Pride
Uveal melanoma Liver metastasis. Mnk1/2 Rab1a Mtor 
UnknownAmino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.
Not available
S-EPMC8062038 | biostudies-literature
UnknownRab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.
Not available
S-EPMC8355269 | biostudies-literature
ProteomicsHuman Uveal Melanome-surfaceome
A quantitative surface biotin-labeling approach combined with mass spectrometry was used to identify differentially expressed surface proteins in uveal melanoma (UM) cells, in which RAB1A was either knocked down or overexpressed, compared with the respective controls.
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD069080 | Pride
Uveal melanome Surface proteome 
UnknownDual function of Rab1A in secretion and autophagy: hypervariable domain dependence.
Not available
S-EPMC9939007 | biostudies-literature
UnknownRAB1A haploinsufficiency phenocopies the 2p14-p15 microdeletion and is associated with impaired neuronal differentiation.
Not available
S-EPMC10722380 | biostudies-literature
UnknownIncreased Rab1a accelerates osteoarthritis by inhibiting autophagy via activation of the mTORC1-S6K pathway.
Not available
S-EPMC12789720 | biostudies-literature
UnknownATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis.
Not available
S-EPMC11974814 | biostudies-literature
UnknownHsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions.
Not available
S-EPMC4011886 | biostudies-literature
UnknownRab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma.
Not available
S-EPMC7655155 | biostudies-literature
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