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TranscriptomicsGene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan
In patients with advanced colorectal cancer, leucovorin, fluorouracil, and irinotecan (FOLFIRI) is considered as one of the reference first-line treatments. However, only about half of treated patients respond to this regimen, and there is no clinically useful marker that predicts response. A major ...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-62080 | biostudies-arrayexpress
TranscriptomicsSpecific extracellular matrix remodeling signature of colon hepatic metastases [HG-U133B]
To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. W...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-62321 | biostudies-arrayexpress
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