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UnknownA Solution for the Remote Care of Frail Elderly Individuals via Exergames.
Internet of Things (IoT) solutions are a concrete answer to many needs in the healthcare framework since they enable remote support for patients and foster continuity of care. Currently, frail elderly people are among end users who most need and would benefit from IoT solutions from both a social an...
S-EPMC8069394 | biostudies-literature
UnknownNovel approaches for the treatment of unresectable malignant pleural mesothelioma: A focus on immunotherapy and target therapy (Review).
Malignant pleural mesothelioma (MPM) is considered a relatively uncommon disease but its incidence is increasing worldwide. Patients affected by MPM have a very severe prognosis and have been often occupationally and environmentally exposed to asbestos. In recent years, checkpoint inhibitors have dr...
S-EPMC8892433 | biostudies-literature
UnknownCertolizumab pegol in a heterogeneous population of patients with moderate-to-severe rheumatoid arthritis.

Aim

To determine the efficacy and safety of certolizumab pegol for the treatment of rheumatoid arthritis in a real-world setting.

Materials & methods

Patients with moderate-to-severe rheumatoid arthritis who initiated therapy with certolizumab were followed for 12 weeks. Response was ...
S-EPMC5905631 | biostudies-literature
UnknownTherapeutic Implications of Tumor Microenvironment in Lung Cancer: Focus on Immune Checkpoint Blockade.
In the last decade, the treatment of non-small cell lung cancer (NSCLC) has been revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against programmed death protein 1 (PD-1) and its ligand (PD-L1), or cytotoxic T lymphocyte antigen 4 (CTLA-4). In spite of these improve...
S-EPMC8777268 | biostudies-literature
UnknownLong-term follow-up in common variable immunodeficiency: the pediatric-onset and adult-onset landscape.

Introduction

The primary aim of this study is to investigate the evolution of the clinical and laboratory characteristics during the time in a longitudinal cohort of pediatric-onset and adult-onset Common Variable Immunodeficiency (CVID) patients in order to identify early predictive feature...
S-EPMC10332319 | biostudies-literature
UnknownStudy of thulium-167 cyclotron production: a potential medically-relevant radionuclide.
Introduction: Targeted Radionuclide Therapy is used for the treatment of tumors in nuclear medicine, while sparing healthy tissues. Its application to cancer treatment is expanding. In particular, Auger-electron emitters potentially exhibit high efficacy in treating either small metastases or...
S-EPMC10620610 | biostudies-literature
UnknownCitrate anion improves chronic dialysis efficacy, reduces systemic inflammation and prevents Chemerin-mediated microvascular injury.
Systemic inflammation and uremic toxins (UT) determine the increased cardiovascular mortality observed in chronic hemodialysis (HD) patients. Among UT, the adipokine Chemerin induces vascular dysfunction by targeting both endothelial and vascular smooth muscular cells (EC and VSMC). As Citrate anion...
S-EPMC6650610 | biostudies-literature
UnknownOntogeny of Diet and Behavior of a Wild, Critically Endangered Lemur (Indri indri).
The early developmental period plays a key role in primate behavioral outcomes. Understanding the behavioral ecology of infant indris (Indri indri) helps to identify resources needed during early developmental stages, the weaning process, and the role of mothers in developing infants' survival abili...
S-EPMC12712748 | biostudies-literature
UnknownDeep Learning Can Differentiate IDH-Mutant from IDH-Wild GBM.
Isocitrate dehydrogenase (IDH) mutant and wildtype glioblastoma multiforme (GBM) often show overlapping features on magnetic resonance imaging (MRI), representing a diagnostic challenge. Deep learning showed promising results for IDH identification in mixed low/high grade glioma populations; however...
S-EPMC8069494 | biostudies-literature
UnknownDevelopments toward the Implementation of 44Sc Production at a Medical Cyclotron.
44Sc has favorable properties for cancer diagnosis using Positron Emission Tomography (PET) making it a promising candidate for application in nuclear medicine. The implementation of its production with existing compact medical cyclotrons would mean the next essential milestone in the development of...
S-EPMC7587374 | biostudies-literature
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