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TranscriptomicsFAIRE-chip in CHRF-288-11 and K562 cells
Maps of open chromatin in a megakaryocytic (CHRF-288-11) and an erythroblastoid (K562) cell line using the formaldehyde-assisted isolation of regulatory elements (FAIRE) method. We profiled chromatin structure at 62 non-redundant genetic loci representing all known associations (as of November 2009,...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-25716 | biostudies-arrayexpress
TranscriptomicsWhole-genome gene expression profiling of Pik3cg-depleted mice
We performed whole-genome gene expression profiling in Pik3cg-/- mice and subsequent gene ontology clustering of differentially expressed genes compared to wild type mice, in order to investigate the role of Pik3cg in platelet membrane biogenesis and blood coagulation. Pik3cg-deficient mice were obt...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-26111 | biostudies-arrayexpress
TranscriptomicsHuman Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20236 | biostudies-arrayexpress
TranscriptomicsHuman Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20242 | biostudies-arrayexpress
GenomicsGenome wide association study of Coeliac Disease
We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls. Variants from 13 new regions r...
EGAS00000000057 | EGA
GenomicsDNA methylation and the adverse metabolic outcomes of adiposity
Overweight and obesity affect ~1.5 billion people worldwide, and are major risk factors for type-2 diabetes (T2D), cardiovascular disease and related metabolic and inflammatory disturbances.1,2 Although the mechanisms linking adiposity to its clinical sequelae are poorly understood, recent studies s...
EGAS00001001922 | EGA
GenomicsBMI EWAS summary stats
Summary statistics for a multi-cohort epigenome-wide association study. This includes summary statistics (effect-size, standard error, p-value) for 470,000 methylation markers.
EGAD00010001029 | EGA
TranscriptomicsMethylation profiling by array of subcutaneous fat derived from 856 TwinsUK participants
Epigenetic changes such as DNA methylation variation are known to play a role in gene regulation and common disease susceptibility. Little is known about the genome-wide frequency, localization and function of such changes and how they are regulated by genetic and environmental factors. We have util...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-MTAB-1866 | biostudies-arrayexpress
TranscriptomicsCommon regulatory variation impacts gene expression in a cell type dependent manner
Studies correlating genetic variation to gene expression facilitate the interpretation of common human phenotypes and disease. As functional variants may be operating in a tissue-dependent manner, we performed gene expression profiling and association with genetic variants (SNPs) on three cell types...
ORGANISM(S): Homo sapiens 
2010-08-20 | E-GEOD-17080 | biostudies-arrayexpress
GenomicsUC
WTCCC2 project Ulcerative Colitis (UC) samples
EGAD00000000025 | EGA
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