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Sinusoidal obstruction syndrome (SOS; formerly veno-occlusive disease) is a well-established complication of hematopoietic stem cell transplantation, pyrrolizidine alkaloid intoxication, and widely used chemotherapeutic agents such as oxaliplatin. It is associated with substantial morbidity and mort...
ORGANISM(S): Homo sapiens 
Budding yeast telomeres and cryptic mating-type loci are anchored at the nuclear envelope, forming foci that sequester Silent information regulators (SIR factors), much as heterochromatic chromocenters in higher eukaryotes sequester HP1. Here we examine the impact of such subcompartments for regulat...
ORGANISM(S): Saccharomyces cerevisiae 
To reveal changes in chromatin state and correlate with transcriptional activity during embryonic development
ORGANISM(S): Mus musculus 
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