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ProteomicsProteomics analysis of muscles from long lived O1/O3 flies in young and old age (Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations) Liam C. Hunt, Jianqin Jiao, Yong-Dong Wang, David Finkelstein, Deepti Rao, Michelle Curley, Maricela Robles-Murguia, Abbas Shirinifard, Vishwajeeth R. Pagala, Junmin Peng, Yiping Fan, and Fabio Demontis. Genome Research In press 2019.
Protein expression profiles in the whole tissue lysate extracted from the thorax of O1 and O3 long-lived flies with the control B3 strain flies and analyzed by tandem mass tag (TMT)–based mass spectrometry.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-06-13 | PXD014223 | Pride
Genomic analyses of aging  evolution of aging  circadian muscle transcriptome  longevity  circadian cycle  skeletal muscle  sarcopenia  proteostasis  timeless  drosophila 
TranscriptomicsMLX transcriptional regulation in muscle cells
This study set out to identify MLX transcriptional targets in muscle cells. C2C12 Myoblasts were virally transduced to increase MLX activity, by overexpression of the wild-type protein; and to decrease MLX activity by overexpression of a dominant negative MLX protein and by shRNA induced knockdown o...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-70028 | biostudies-arrayexpress
ProteomicsProtein solubility changes in mouse liver tissue during aging
Protein solubility changes in mouse liver tissue during aging
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD070425 | Pride
Protein solubility  insolubilome  proteostasis  aging  protein quality control  mouse. 
ProteomicsProtein solubility changes in mouse hippocampus during aging
Protein solubility changes in mouse hippocampus during aging
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD057313 | Pride
Protein solubility  insolubilome  proteostasis  aging  protein quality control  mouse. 
ProteomicsProtein solubility changes in mouse neocortex during aging.
Protein solubility changes in mouse neocortex during aging.
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD057311 | Pride
Protein solubility  insolubilome  proteostasis  aging  protein quality control  mouse. 
ProteomicsProtein solubility changes in mouse tibialis anterior during aging
Protein solubility changes in mouse tibialis anterior during aging
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD057317 | Pride
Protein solubility  insolubilome  proteostasis  aging  protein quality control  mouse. 
ProteomicsProtein solubility changes in mouse soleus tissue during aging
Protein solubility changes in mouse soleus tissue during aging
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD057315 | Pride
Protein solubility  insolubilome  proteostasis  aging  protein quality control  mouse. 
ProteomicsProtein solubility changes in mouse cerebellum during aging
Protein solubility changes in mouse cerebellum during aging
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD057314 | Pride
Protein solubility  insolubilome  proteostasis  aging  protein quality control  mouse. 
ProteomicsProtein solubility changes in mouse serum during aging
Protein solubility changes in mouse serum during aging
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD057320 | Pride
Protein solubility  insolubilome  proteostasis  aging  protein quality control  mouse. 
ProteomicsProtein solubility changes in mouse liver tissue during aging.
Protein solubility changes in mouse liver tissue during aging.
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD057309 | Pride
Protein solubility  insolubilome  proteostasis  aging  protein quality control  mouse. 
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