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TranscriptomicsTranscription profiling of wild type and Sox9 knock out mice to study the role of Sox 9 (testis determining gene) after testis induction
To study the role of the testis determining gene Sox9 after testis induction, conditional inactivation of Sox9 was achieved with the help of an AMH-Cre line. Mutant mice are fertile up to about 3 months of age, becoming sterile afterwards. Expression profiles should help to reveal the underlying cau...
ORGANISM(S): Mus musculus 
2010-07-01 | E-TABM-528 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice mutant for Sox8 and Sox9 has early testicular sterility
To study a possible redundant role of mouse Sox8 and Sox9 after testis induction we generated double mutants by AMH-Cre conditional inactivation of Sox9 in a Sox8-/- background. Double mutants arrest spermatogenesis in early pubescence. We performed expression profiling to explore causes. AMH-Cre/+...
ORGANISM(S): Mus musculus 
2013-01-03 | E-TABM-531 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation to determine binding of ARS binding factor 1 (Abf1) in yeast during vegetative growth and meiotic development
Binding of the yeast ARS binding factor 1 (Abf1) to target promotors during vegetative growth and meiotic development as tested by ChIP-CHIP analysis;
ORGANISM(S): Saccharomyces cerevisiae 
2008-05-01 | E-MEXP-1439 | biostudies-arrayexpress
TranscriptomicsEGR4 is a master gene responsible for fertility in cryptorchidism
RNA was isolated from testicular biopsies of cryptorchid boys. Gene expression profiles for these samples were investigated using Affymetrix arrays Whole testicular tissue was gained from cryptorchid boys aged 10 Months to 4.5 years as well as from controls of identical age. Each biopsy sample was c...
ORGANISM(S): Homo sapiens 
2009-09-01 | E-GEOD-16191 | biostudies-arrayexpress
GenomicDifferential Gene Expression in Cryptorchid Testes

Differential Gene Expression in Cryptorchid Testes Study uses whole-genome RNA profiling of testicular biopsies to determine a potential causative role of isolated congenital cryptorchidism in azoospermia and/or infertility in the context of our previously published GeneChip data. Cryptorchid pat...

phs001275 | dbGaP
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