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TranscriptomicsHepatic Gene Expression Changes in Diethynitrosamin-initiated and Cholic Acid promoted tumors
Mice were fed with either normal diet (ND), 0.2% cholic acid diet (0.2%CA), DEN treated and fed ND or DEN treated and fed 0.2%CA diet. DEN was treated at 15 microgram/kg body weight at postnatal day 15. Diets were fed for two months starting 8 months of age till 10 months of age. Livers were collect...
ORGANISM(S): Mus musculus 
2016-08-10 | E-GEOD-75445 | biostudies-arrayexpress
TranscriptomicsExpression data from wild-type and HMGN1 knockout mice injected with N-nitrosodiethylamine
HMGN1 contributes to the shortened latency of liver tumorigenesis by changing a chromatin structure and expression of relevant genes To assess the molecular mechanisms underlying accelerated tumor development in Hmgn1-/- mice, we performed the gene expression profiling of liver cells at early stages...
ORGANISM(S): Mus musculus 
2013-08-24 | E-GEOD-44356 | biostudies-arrayexpress
TranscriptomicsInfluence of DEN in mice liver
Hepatocellular carcinoma is the third leading cause of cancer death worldwide, and it is necessary to elucidate the mechanism of hepatocarcinogenesis. Hepatocellular carcinoma (HCC) has a high mortality rate and develops based on the chronic inflammatory hepatic disease. Therefore, novel prophylacti...
ORGANISM(S): Mus musculus 
2014-06-06 | E-GEOD-57798 | biostudies-arrayexpress
TranscriptomicsDEN-induced HCC in c-Met knockout mice
HGF has been reported to have both positive and negative effects on carcinogenesis. Here we show that the loss of c-Met signaling in hepatocytes enhanced rather than suppressed the early stages of chemical hepatocarcinogenesis. c-Met conditional knockout mice (c-metfl/fl, AlbCre+/-; MetLivKO) treate...
ORGANISM(S): Mus musculus 
2008-08-09 | E-GEOD-8747 | biostudies-arrayexpress
ProteomicsProteomic analysis of DEN and CCl4-induced hepatocellular carcinoma mouse model
DEN and CCl4-induced HCC mouse model was constructed, and the proteome of HCC and liver tissues was analyzed.
ORGANISM(S): Mus Musculus 
2024-02-04 | PXD049148 |
TranscriptomicsDifferential expression in DEN/CCl4-induced HCC upon the genetic absence of Autotaxin (ATX) in hepatocytes
Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalyzing the production of lysophosphatidic acid (LPA), a pleiotropic growth factor-like phospholipid. Upregulated ATX expression has been detected in various chronic inflammatory disorders and different types of cancer; among them increased...
ORGANISM(S): Mus musculus 
2016-11-30 | E-MTAB-4648 | biostudies-arrayexpress
TranscriptomicsGene-expression profiles of liver and hepatocellular carcinoma induced by diethylnitrosamine (DEN) in KLF6 +/- and wild type KLF6 mice.
Gene-expression profiles of liver and hepatocellular carcinoma induced by diethylnitrosamine (DEN) in KLF6 +/- and wild type KLF6 mice. Inactivation of the KLF6 tumor suppressor is common in HCC due to hepatitis C virus (HCV), consistent with its anti-proliferative activity in HCC-derived cell lines...
ORGANISM(S): Mus musculus 
2011-07-31 | E-GEOD-23375 | biostudies-arrayexpress
Modelsden Breems2015 - macrophage in cancer
The paper describes a model of re-polarisation of M2 and M1 macrophages and its role on cancer outcomes. Created by COPASI 4.25 (Build 207) This model is described in the article: The re-polarisation of M2 and M1 macrophages and its role on cancer outcomes den Breems, Nicoline Y.; Eftimie, Raluc...
2024-09-02 | BIOMD0000000759 | BioModels
Immuno-oncology 
TranscriptomicsMouse frozen liver: vehicle-control vs. CCl4+DEN treated
Hepatocellular carcinoma (HCC) is a prevalent human cancer with rising incidence worldwide. Human HCC is frequently associated with chronic liver inflammation and cirrhosis, pathophysiological processes that are a consequence of chronic viral infection, disturbances in metabolism, or exposure to che...
ORGANISM(S): Mus musculus 
2015-11-01 | E-GEOD-71849 | biostudies-arrayexpress
GenomicsDEN-induced rat model reproduces key features of human hepatocellular carcinoma
DEN-induced rat model reproduces key features of human hepatocellular carcinoma
PRJNA758075 | ENA
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