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no omics definedTranscription profiling of mouse pluripotent embryocarcinoma cell line P19 after sodium valproate treatment to investigate its mechanism of teratogenicity
In the process of evaluating teratogenic properties of xenobiotica, the consumption of laboratory animals is high and costly which makes the development of alternative methods desirable. The pluripotent embryocarcinoma cell line P19, which closely resembles the early stage of an embryo, may be relev...
ORGANISM(S): Mus musculus 
2008-01-23 | E-MEXP-981 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chicken 18 day embryonic chicken heart, brain, and gonad to determine sex specific gene expression
The contrasting dose of sex chromosomes in males and females potentially introduces a large-scale imbalance in levels of gene expression between sexes. In many organisms dosage compensation has thus evolved to equalize sex-linked gene expression in males and females1,2, in mammals achieved by X chro...
ORGANISM(S): Gallus gallus 
2008-11-06 | E-GEOD-8693 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Cadmium induced defects in the embryo 5 h after maternal Cd exposure in the absence or presence of Zn pretreatment
Cadmium (Cd) administered to female C57BL/6 mice on gestation day 8 induces a high incidence of anterior neural tube defects (exencephaly). This adverse effect can be attenuated by maternal pretreatment with zinc (Zn). In this study we used replicated microarray analysis to investigate gene expressi...
ORGANISM(S): Mus musculus 
2006-04-11 | E-MEXP-529 | biostudies-arrayexpress
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