Dendritic cell maturation

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Organisms

Mus musculus (160)
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Liquid Chromatography MS - positive - reverse phase (2)
Single nuclei were captured using the 10x Genomics Chromium Controller. (1)
Affymetix Gene Titan (1)
Affymetrix Gene Titan (1)
Agilent 2100 Bioanalyser, RNA 6000 Nano Kit chips (Agilent Technologies). NanoDrop® ND-1000 (Saveen&Werner). (1)
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CHEBI ID

CHEBI:16761 (2)
CHEBI:167922 (1)
CHEBI:32664 (1)
CHEBI:17536 (1)
CHEBI:456215 (1)
CHEBI:28013 (1)
CHEBI:42111 (1)
CHEBI:15676 (1)
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CHEBI:30838 (1)
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CHEBI:30887 (1)
CHEBI:32805 (1)
CHEBI:44897 (1)
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CHEBI:30769 (1)

Metabolite Name

Phosphoenolpyruvate (2)
Beta-D-fructofuranose 1,6-bisphosphate (1)
2/3-Phosphoglycerate (1)
Cystine_639 (1)
Tryptophan_375 (1)
Histidine_440 (1)
3PG_585 (1)
Citrate_591 (1)
Adenine_306 (1)
Glutamine_431 (1)
Lysine_431 (1)
NAA_3TBDMS_460 (1)
Glutamate_432 (1)
Ornithine_474 (1)
2-Hydroxyglutarate_433 (1)
NAA_ASP_287 (1)
Aspartate_418 (1)
Malate_419 (1)
A-Ketoglutarate_346 (1)
Cytosine_282 (1)
Methionine_320 (1)
Serine_390 (1)
Itaconate_301 (1)
Fumarate_287 (1)
Succinate_289 (1)
GABA_274 (1)
Isoleucine_302 (1)
Leucine_302 (1)
Valine_288 (1)
Glycine_246 (1)

IsPrivate

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First Public Date

2026 (57)
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2021 (20)
2020 (17)
2022 (15)
2019 (12)
2017 (12)
2015 (9)
2018 (6)
2016 (6)
2013 (2)

Modelling Approach

Agent-based model (1)

Study type

Transcription profiling by array (147)
RNA-seq of coding RNA (11)
ChIP-seq (6)
Methylation profiling by array (3)
Human - High-throughput sequencing (2)
RNA-seq of coding RNA from single cells (2)
RNA-seq of non coding RNA (2)
Unknown experiment type (1)
Transcription profiling by RT-PCR (1)
Other (1)
Single nucleus RNA sequencing (1)
MicroRNA profiling by array (1)
Proteomic profiling by array (1)

Release Date

2025 (203)
2022 (192)
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2014 (111)
2015 (105)
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2011 (76)
2012 (69)
2013 (66)
2010 (59)
2026 (45)
2009 (40)
2008 (28)
2007 (21)
2006 (21)
2004 (5)
2005 (4)
2003 (2)
1999 (2)
1997 (2)
1998 (1)

Lab affiliation

Department of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic (2)
Newcastle University Instite for Cell and molecular Biosciences (ICAMB) Framglinton place, N2E4HH Newcastle Upon Tyne, UK (1)
Department of Molecular Systems Biology, Helmholtz-Centre for Environmental Research - UFZ (1)
Center of experimental therapeutics Department of oncology UNIL CHUV Ludwig Institute for Cancer Research Lausanne Centre de recherche Agora Rue du Bugnon 25A CH-1005 Lausanne (1)
Intravacc, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands (1)
Istituto Italiano di Tecnologia Via Morego 30, 16163 Genova Italy (1)
Englander Institute of Precision Medicine Professor Radiation Oncology Professor Physiology and Biophysics Weill Cornell Medicine 1300 York Avenue Room E215 New York, NY 10065 tel 646-962-2160 (1)
Consultant Medical oncology (1)
Bioheat and mass transfer laboratory, Med-X Research Institute, Shanghai Jiao Tong University (1)
Group Leader, Quattrocolo Lab, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway (1)
Institut für Medizinische Mikrobiologie und Hygiene Universitätsklinikum Tübingen Elfriede-Aulhorn-Str. 6, 72076 Tübingen Germany (1)
Bioanalytical Research Labs, Department of Biosciences & Medical Biology, Universität Salzburg, Austria (1)
Paul R crocker: Professor of Glycoimmunology and Head of the Division of Cell Signalling and Immunology (1)
Institute for Immunology Ludwig-Maximilians-University D-80336 Munich Germany (1)
università degli studi di Milano, medicina veterinaria, DIMEVET (1)
Center of Excellence in Systems Biology, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand (1)
Department of Molecular Biology, Princeton University (1)
ETH Zurich, D-HEST, Lab of Systems Neuroscience (1)
Department of Neurology, Nagoya University Graduate School of Medicine (1)
School of Medicine, University of St Andrews, St Andrews, KY16 9TF, UK (1)
Professor of Pathology Endowed Chair in Immunology Research University of Iowa Health Care Distinguished Scholar Department of Pathology The University of Iowa Tel: 319-335-1121 (O)/319-335-0990 (Lab) (1)
Target Discovery Institute, University of Oxford (1)
College of Veterinary Medicine, South China Agricultural University, Guangzhou, China (1)
MIRCen, UMR9199, CEA, CNRS, Université Paris-Saclay (1)
Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada; Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada; The Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Alberta, Canada (1)
Proteomics Core Facility, Biozentrum, University of Basel, Switzerland (1)

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HERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION

Herpes simplex virus type 1 (HSV-1) infects dendritic cells (DCs), professional antigen-presenting cells that initiate and regulate host antiviral responses. HSV-1 infects DCs limiting their maturation, migration to draining lymph nodes and T cell activation capacity, ultimately promotes their apopt...

2025-04-03 | MTBLS5163 | MetaboLights

Pharmacological Targeting of ALDH1a2 in Dendritic Cells Enhances Antigen Presentation, T Cell Activation and Anti-tumor immunity

Dendritic cell (DC) vaccines have been proposed as cancer immunotherapies due to their role as crucial antigen-presenting cells that regulate T cell functions. Despite considerable efforts to optimize ex vivo priming of DCs, DC vaccines have rarely been successful, suggesting the presence of unknown...

2025-11-03 | MTBLS10389 | MetaboLights

miRNA expression profiling of human monocyte-derived dendritic cells (moDCs) during maturation

miRNA expression profiling of human monocyte-derived dendritic cells (moDCs) during maturation. Immature, 4h and 16h LPS-activated moDCs were used. In this study were analysed 2 biological samples of RNA extracted from 4h-post LPS stimulation moDCs and 2 bfrom 16h-post LPS stimulation. The RNA ...

ORGANISM(S): Homo sapiens

2010-05-15 | E-GEOD-13369 | biostudies-arrayexpress

Transcription profiling of human dendritic cells matured by cadherin reveals disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation

The maturation of dendritic cells (DCs) after exposure to microbial products or inflammatory mediators plays a critical role in initiating the immune response. We found that maturation can also occur under steady state conditions, triggered by alterations in E-cadherin-mediated DC-DC adhesion. Sele...

ORGANISM(S): Homo sapiens

2008-06-16 | E-GEOD-9241 | biostudies-arrayexpress

Effect of LMP7 and MECL1-immunoproteasome subunits deficiency on the transcriptome of mouse bone marrow-derived dendritic cells

As regulators of protein degradation, proteasomes regulate practically all cellular functions. It is therefore logical to assume that replacement of the constitutive proteasome (CP) by its IFN- inducible homolog immunoproteasome (IP) could have far reaching effects on cell function. Accordingly, re...

ORGANISM(S): Mus musculus

2014-07-02 | E-GEOD-52616 | biostudies-arrayexpress

miR-155 KO in human dendritic cells

In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-deri...

ORGANISM(S): Homo sapiens

2009-03-04 | E-GEOD-13296 | biostudies-arrayexpress

Proteome and phophoproteome analysis of distinct dendritic cell maturation states

Depending on their environment and their exposure to various factors, dendritic cells (DCs) exist in different activation and maturation states. The versatility of DCs allows them to shape the immune system towards an inflammatory or tolerant state depending on the antigens and the environment they ...

ORGANISM(S): Mus musculus (Mouse)

2017-11-27 | PXD003738 | Pride

Transcription profiling of human dendritic cell maturation revealed by integration of proteome and transcriptome at the pathway level

Day 6 human monocyte derived dendritic cells were left unstimulated or matured for 2 days using the golden standard maturation cocktail currently used in clinical practice. Maturation induced changes in mRNA expression were determined by calculation of expression in mature DC relative to immature DC...

ORGANISM(S): Homo sapiens

2010-03-24 | E-MEXP-2290 | biostudies-arrayexpress

Human monocyte-derived dendritic cells treated with U0126 or SB203580

Identification of MEK-ERK or p38MAPK dependent genes in human monocyte derived dendritic cells. Dendritic cells (DC) promote tolerance or immunity depending on their maturation state. Previous studies have revealed that DC maturation is enhanced or accelerated upon MEK-ERK signaling pathway inhibiti...

ORGANISM(S): Homo sapiens

2013-05-03 | E-GEOD-39745 | biostudies-arrayexpress

Quantitative analysis of large-scale proteomic changes in LPS-activated monocyte-derived dendritic cells: A SWATH-MS study

Determination of global alterations in monocyte-derived dendritic cells in response to stimulation with lipopolysaccharide using SWATH-MS to provide insight into cellular mechanism driving dendritic cell maturation

ORGANISM(S): Homo sapiens (Human)

2019-03-18 | PXD008898 | Pride

Lipopolysaccharide Antigen presentation Leukocyte metabolism Quantitative proteomics Dendritic cell maturation

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