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Gene expression and H3K27ac changes upon Rat gastrognemius muscle denervation
Analysis of denervation induced regulation of muscle mass at gene expression level. The hypothesis tested in the present study was that the presence of MuRF1 contributes to the extent of gene expression changes observed in specific sets of genes during a challenge leading to muscle atrophy. Results ...
ORGANISM(S): Mus musculus 
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during the chronic denervation that results from slow axon growth. This impairs axonal regeneration and ca...
ORGANISM(S): Mus musculus 
Effects of Denervation on Muscle Function
Background: Skeletal muscle crucially depends on motor innervation, and, when damaged, on the resident muscle stem cells (MuSCs). However, the role and function of MuSCs in the context of denervation remains poorly understood. Methods: Alterations of MuSCs and their myofiber niche after denervation...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-27 | PXD036993 | Pride
m6A MeRIP-seq of skeletal muscle during innervation and denervation
Background: Patients with neurodevelopmental and neuromuscular disorders often show overlapping clinical phenotypes. Pathogenic variants in KMT5B, a histone lysine methyltransferase, have been linked to neurodevelopmental disorders, yet their effects on human skeletal muscle remain unexplored. We re...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-01-05 | PXD071037 | Pride
Gene expression analysis in murine muscle stem cells after denervation
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