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TranscriptomicsTwo Supporting Factors Greatly Improve the Efficiency of Human iPS Cell Generation
Human fibroblasts can be induced into pluripotent stem cells (iPS cells), but the reprogramming efficiency is quite low. Here, we screened a panel of candidate factors in the presence of OCT4, SOX2, KLF4 and c-MYC in an effort to improve the reprogramming efficiency from human adult fibroblasts. We ...
ORGANISM(S): Homo sapiens 
2008-11-06 | E-GEOD-12922 | biostudies-arrayexpress
TranscriptomicsGeneration of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts
Induced pluripotent stem (iPS) cells can be generated from somatic cells by transduction with several transcription factors in both mouse and human. However, direct reprogramming in other species has not been reported. Here, we established an efficient method to generate monkey iPS cells from fibrob...
ORGANISM(S): Macaca mulatta 
2010-05-15 | E-GEOD-13146 | biostudies-arrayexpress
TranscriptomicsInduction of pluripotency in mouse somatic cells with lineage specifiers (RNA-seq)
For years, reprogramming factors that induce pluripotency have been identified primarily from ESC-enriched factors, pluripotency-associated factors such as Oct4, Sox2, Klf4, c-Myc, Nanog, Esrrb, Sall4, Utf1, Lin28, PRDM14, and Tet2. Through genome-wide screen we identified novel regulators of reprog...
ORGANISM(S): Mus musculus 
2013-05-28 | E-GEOD-47442 | biostudies-arrayexpress
TranscriptomicsInduction of pluripotency in mouse somatic cells with novel factors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-05-28 | E-GEOD-43995 | biostudies-arrayexpress
TranscriptomicsInduction of pluripotency in mouse somatic cells with novel factors (expression)
For years, reprogramming factors that induce pluripotency have been identified primarily from ESC-enriched factors, pluripotency-associated factors such as Oct4, Sox2, Klf4, c-Myc, Nanog, Esrrb, Sall4, Utf1, Lin28, PRDM14, and Tet2. Through genome-wide screen we identified novel regulators of reprog...
ORGANISM(S): Mus musculus 
2013-05-28 | E-GEOD-47441 | biostudies-arrayexpress
TranscriptomicsGeneration of Naïve Induced Pluripotent Stem Cells from Rhesus Monkey Fibroblasts
Conventional embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) derived from primates resemble mouse epiblast stem cells, raising an intriguing question regarding whether the naïve pluripotent state resembling mouse embryonic stem cells (mESCs) exists in primates and how to captur...
ORGANISM(S): Macaca mulatta 
2014-10-14 | E-GEOD-61420 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptional analysis of mouse fibroblasts, chemically-induced neurons (neuron-like cells) from mouse fibroblasts and mouse primary cortical neurons by RNA-seq
Recently, direct reprogramming between divergent lineages has been achieved by introducing cell-fate-determining transcription factors. This progress may provide alternative cell resources for drug discovery and regenerative medicine. However, the genetic manipulation may limit the future applicatio...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-68715 | biostudies-arrayexpress
Transcriptomicscardiomyocyte induced from fibroblast
the fibroblast from the skin of the mouse dorsum become the cardiomyocyte do a lot of experiment and gradually find out the best combination of the induction
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-32605 | biostudies-arrayexpress
TranscriptomicsInducing pluripotency from mouse somatic cells by small-molecule compounds [RNA-Seq]
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource for regenerative medicine. However, genetic manipulation and difficult-to-manufacture strategies used in reprogramming limit their clinical applications. Here, we show pluripotency can be induced from mous...
ORGANISM(S): Mus musculus 
2013-07-22 | E-GEOD-48252 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing analysis of NGN3-GFP positive and negative cells purified from differentiating human embryonic stem cells
NGN3-eGFP could be used to mark endocrine progenitor cells and their progeny in differentiating hESCs, suggesting that profiling analysis of NGN3-eGFP+ cells could lead to the discovery of novel gene participation. Six batches of NGN3-eGFP+ and NGN3-eGFP -cells purified by FACS from a reporter hES c...
ORGANISM(S): Homo sapiens 
2014-09-12 | E-GEOD-54879 | biostudies-arrayexpress
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