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MetabolomicsUrinary Ubiquitin-Specific Protease 2 (USP2) as a Diagnostic Biomarker for Chronic Kidney Disease: An Integrated Multi-Omics and Network Analysis
Urinary USP2 is elevated in chronic kidney disease and shows strong diagnostic performance. Integrated metabolomics and proteomics analyses identified cortisol and prostaglandin A3 as candidate mediators and linked USP2 to lipid metabolism and ferroptosis-related pathways.
2026-05-05 | MTBLS14426 | MetaboLights
ProteomicsPeritoneal Dialysis in Neuropsychiatric Systemic Lupus Erythematosus: A Case Report Integrating Proteomic Insights into Complement-Mediated Mechanisms
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe complication of systemic lupus erythematosus (SLE), characterized by heterogeneous neurological manifestations. Current therapies, such as plasma exchange (PE), are limited by cardiovascular risks and resource availability. This case ...
ORGANISM(S): Homo Sapiens 
PXD062706 |
ProteomicsProteomic Insights into Aprotinin’s Immunomodulatory Effects in Attenuating Renal Fibrosis in a Unilateral Ureteral Obstruction Model
Chronic kidney disease (CKD) is characterized by progressive renal fibrosis and immune dysregulation. Aprotinin, a broad-spectrum serine protease inhibitor, has shown dose-dependent effects on kidney function, but its role in chronic obstructive nephropathy remains unclear.
ORGANISM(S): Mus Musculus 
PXD063655 |
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