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ProteomicsTargeting an RNA polymerase II-associated PHF5A protein subcomplex with a KMT2A-WDR5 inhibitor impairs self-renewal and tumorigenicity of pancreatic cancer stem cells
Pancreatic cancer (PC) remains one of the most aggressive and life-threatening malignancies known for its notorious resistance to chemotherapy. This is increasingly ascribed to the subpopulation of undifferentiated cells, known as pancreatic cancer stem cells (PCSCs), which are evolutionary fitter t...
ORGANISM(S): Homo sapiens (Human) 
2023-08-23 | PXD038378 | Pride
Epigenetics Cancer stem cells Pancreatic cancer Phf5a complex Kmt2a-wdr5 inhibitor 
UnknownLyophilization process optimization and molecular dynamics simulation of mRNA-LNPs for SARS-CoV-2 vaccine.
Not available
S-EPMC10562438 | biostudies-literature
TranscriptomicsRNA-seq of definitive endoderm differentiation of human embryonic stem cells in early G1 phase of the cell cycle
The experiment was designed to investigate transcriptional dynamics during definitive endoderm differentiation of human embryonic stem cells (hESCs) in early G1 phase of the cell cycle. For this, the FUCCI system was used to sort hESCs in Early G1 (EG1). Samples were taken at 0h (hESCs), 12h, 24h, 3...
ORGANISM(S): Homo sapiens 
2020-09-07 | E-MTAB-9194 | biostudies-arrayexpress
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