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ProteomicsTarget of Dleu2-17aa in CD4+ T cells
To identify Dleu2-17aa micropeptide interacting proteins in CD4+ T cells, we performed pull-down assays fllowed by LC-MS using biotin-labeled Dleu2-17aa. As controls, we included the unlabeled free Dleu2-17aa and a biotin-only group. Pull-downs were carried out in both primary mouse CD4+ T cells and...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-23 | PXD046468 | Pride
Cd4+ t cells Micropeptide 
ProteomicsAutophagy Deficiency Promotes Triple-Negative Breast Cancer Resistance to T Cell-Mediated Cytotoxicity by Blocking Tenascin-C Degradation
Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast cancer is the disease genetically linked to a deficiency in autophagy. Here, we show that autophagy promotes tumour imm...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-05 | PXD019947 | Pride
Tnbc Tenascin-c T cell-mediated killing Autophagy deficiency Immune checkpoint inhibitors 
ProteomicsAutophagy Deficiency Promotes Triple-Negative Breast Cancer Resistance to T Cell-Mediated Cytotoxicity by Blocking Tenascin-C Degradation
Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast cancer is the disease genetically linked to a deficiency in autophagy. Here, we show that autophagy promotes tumour imm...
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD019946 | Pride
Tnbc Tenascin-c T cell-mediated killing Autophagy deficiency Immune checkpoint inhibitors 
ProteomicsCDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF-Induced Functional Orchestration of Tumor-Associated Macrophages
Cyclin-dependent kinases 4 and 6 (CDK4/6) regulate cell cycle progression from the G1 to S phase. Recent findings have demonstrated that CDK4/6 inhibition (CDK4/6i) enhances antitumor immunity, as evidenced by increased tumor infiltration of CD8+ T cells, though the underlying mechanism remains uncl...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD057791 | Pride
Cdk4/6 inhibitor  breast cancer  macrophage  cd8+t cell 
UnknownRegulation of blood-testis barrier assembly in vivo by germ cells.
Not available
S-EPMC6137450 | biostudies-literature
UnknownLentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner.
Not available
S-EPMC6206909 | biostudies-literature
ProteomicsThe exploration of brain-body interactions of brain injury reveals organ-specific and diverse signatures
The importance of brain-body interactions in the progresses of diseases are increasingly noticed, and understanding the associated processes could vastly improve the health of whole organism. A comprehensive, whole-organism analysis of organ dynamics to identify the molecular processes within and be...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD055505 | Pride
Proteomics Ischemic stroke Brain-body interactions Brain injury 
UnknownFactors influencing and long-term effects of manual myotomy phenomenon during physiotherapy for congenital muscular torticollis.
Not available
S-EPMC9526270 | biostudies-literature
UnknownDLL1 orchestrates CD8+ T cells to induce long-term vascular normalization and tumor regression.
Not available
S-EPMC8179177 | biostudies-literature
UnknownMulti-omics reveals the impact of Clonorchis sinensis infection on mouse gut microbiota, metabolomics and transcriptomics.
Not available
S-EPMC12659621 | biostudies-literature
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