Sort   by:  
 Page size 
ProteomicsTRAF6 integrates innate immune signals to regulate glucose homeostasis via control of mitophagy
Elevated or chronic innate immune activation plays a role in the progression of metabolic diseases such as diabetes, yet the influence of innate immune signaling on pancreatic β-cells is not well characterized. Here we report that TRAF6, an E3 ubiquitin ligase downstream of TLR signaling, maintains ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-21 | PXD063412 | Pride
Mitochondria Innate immunity Beta cells Metabolic stress 
ProteomicsLONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes
Protein misfolding is a contributor to the development of type 2 diabetes (T2D), but it is unknown whether impaired proteostasis in T2D is generalized or has special features. Here, we report a robust accumulation of misfolded proteins within the mitochondria of human pancreatic islets from patients...
ORGANISM(S): Homo sapiens (Human) 
2025-06-05 | PXD060404 | Pride
Diabetes  apoptosis  mitochondrial protein folding  lonp1 
UnknownCOPI-Mediated Nuclear Translocation of EGFRvIII Promotes STAT3 Phosphorylation and PKM2 Nuclear Localization.
Not available
S-EPMC6329918 | biostudies-literature
Proteomics[HPP-2.0]A simple, rapid, and practical method for single-cell proteomics based on mass-adaptive coating of synthetic peptides
Here, we report a simple, rapid, and practical approach of mass-adaptive coating-assisted single-cell proteomics (Mad-CASP). Combined with the designed synthetic peptides and novel data acquisition strategy, 1240 ± 93 (n = 3) proteins were identified from a single HeLa cell by Mad-CASP.
ORGANISM(S): Homo Sapiens 
2023-10-17 | PXD046177 |
Sort   by:  
 Page size