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TranscriptomicsDengue virus inhibits immune responses in Aedes aegypti cells
The ability of many viruses to manipulate the host antiviral immune response often results in complex host-pathogen interactions. In order to study the interaction of dengue virus (DENV) with the Aedes aegypti immune response, we have characterized the DENV infection-responsive transcriptome of the ...
ORGANISM(S): Aedes aegypti 
2011-10-31 | E-GEOD-33274 | biostudies-arrayexpress
MetabolomicsTMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating Dengue virus infection
Not available
ORGANISM(S): Homo sapiens 
ST002164 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of two strains of Aedes aegypti mosquito, Moyo-in-dry and Moyo-S after infection with Dengue 2 virus
Two different strains of Aedes aegypti mosquito, Moyo-in-dry and Moyo-S, are profiled for their response through time to infection with Dengue 2 virus. Expression is measured using a two-colour custom spotted cDNA array. A mixed strain uninfected sample is hybridized as the reference.
ORGANISM(S): Aedes aegypti 
2009-10-31 | E-MTAB-46 | biostudies-arrayexpress
TranscriptomicsDengue VN Microarray MD and DF study
DNA microarrays and specific RT-PCR assays were used to reveal transcriptional patterns in the blood of children presenting with dengue shock syndrome (DSS) and well-matched patients with uncomplicated dengue. The transcriptome of patients with acute uncomplicated dengue was characterized by a metab...
ORGANISM(S): Homo sapiens 
2008-12-18 | E-GEOD-13052 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of human peripheral blood mononuclear cells (PBMCs) throughout the febrile, critical, and convalescence phases of dengue virus infection
We investigated the abundances and transcriptomic changes of immune cells at several time points over the course of dengue virus infection. The PBMC samples were obtained from one dengue fever (DF) and one dengue hemorrhagic fever (DHF) patients (8 samples in total). The samples were harvested at tw...
ORGANISM(S): Homo sapiens 
2022-02-16 | E-MTAB-9467 | biostudies-arrayexpress
GenomicsDengue virus
Dengue virus Metagenome
PRJNA642088 | ENA
TranscriptomicsInduction of a peptide with activity against a broad spectrum of pathogens in the Aedes aegypti salivary gland, following infection with dengue virus
Dengue viruses (DENV) are generally maintained in a cycle which requires horizontal transmission via their arthropod vector, Ae. Aegypti, to the vertebrate host. One important consequence of this process is the interference of these arboviruses with both invertebrate and vertebrate immune systems. W...
ORGANISM(S): Aedes aegypti 
2011-03-21 | E-GEOD-21528 | biostudies-arrayexpress
TranscriptomicsMOYO-S and MOYO-R responsive genes to dengue-2 infection at 3hr and 18hr post-infection times
We conducted a genome-wide survey of genes in Ae. aegypti females that are transcriptionally responsive upon challenge with dengue virus (serotype-2). The array was designed with 60-mer oligos specific to 16,092 gene transcripts of gene build AaegL1.1 (www. vectorbase.org). The hybridizations were p...
ORGANISM(S): Aedes aegypti 
2011-09-29 | E-GEOD-16563 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to dengue infection in peripheral blood mononuclear cells of Nicaraguan children
We measured fever-day-specific genome-wide transcript abundance patterns in 105 peripheral blood mononuclear cell (PBMC) samples collected from 41 children hospitalized with dengue virus (DENV) infection in Nicaragua, and from 8 healthy controls. DF1 = primary DF; DF2 = secondary DF; DHF = Dengue H...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-38246 | biostudies-arrayexpress
TranscriptomicsGene expression timecourse from Dengue virus infected human endothelial cells
Dengue viruses cause two severe diseases that alter vascular fluid barrier functions, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). While the mechanisms that lead to vascular permeability are unknown, the endothelium plays a central role in regulating fluid and cellular efflux from...
ORGANISM(S): Homo sapiens 
2012-04-10 | E-GEOD-34628 | biostudies-arrayexpress
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