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TranscriptomicsPACT-PKR Pathway Transactivates the Tumor Suppressor RhoB through C/EBPbeta in Cancer Cells with High Akt Activity
Activation of the PI3K/Akt/mTOR pathway in cancers can occur through loss of PTEN. Transcriptional profiling of pathway inhibitors identified the tumor suppressor RhoB as a gene markedly upregulated by lipid-based Akt inhibitors (LBAI). Here, we demonstrate that the C/EBPbeta full-length isoform LAP...
ORGANISM(S): Homo sapiens 
2015-01-29 | E-GEOD-28993 | biostudies-arrayexpress
TranscriptomicsExpression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells
Activation of the serine/threonine kinase Akt contributes to the formation, maintenance, and therapeutic resistance of cancer, which is driving development of compounds that inhibit Akt. Phosphatidylinositol ether lipid analogues (PIAs) are analogues of the products of PI3K that inhibit Akt activat...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-27911 | biostudies-arrayexpress
UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
TranscriptomicsNeonatal beta cells lack the specialized metabolic phenotype of mature beta cells
Fetal and neonatal beta cells have poor glucose-induced insulin secretion and only gain robust glucose responsiveness several weeks after birth. This unresponsiveness may be due to a generalized immaturity of the metabolic pathways normally found in beta cells. Gene expression profile of neonatal (1...
ORGANISM(S): Rattus norvegicus 
2011-02-22 | E-GEOD-24790 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis roots from plants grown in nutrient solutions with various concentrations of nitrate and sucrose
We used Arabidopsis thaliana Col-0 for all experiments. The plants were grown hydroponically on nutrient solution as described previously [Plant J 1999, 18(5):509-519]. Briefly, plants were grown on sand, placed in custom-designed styrofoam rafts, in a growth chamber (EGC, Chagrin Falls, OH, USA) at...
ORGANISM(S): Arabidopsis thaliana 
2006-11-30 | E-MEXP-828 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Characterization of the Phosphate Starvation Response in Schizosaccharomyces pombe [gene expression data]
Inorganic phosphate is an essential nutrient required by organisms for growth. During phosphate starvation, Saccharomyces cerevisiae activates the phosphate signal transduction (PHO) pathway leading to the expression of the secreted acid phosphatase, PHO5. The fission yeast, Schizosaccharomyces pomb...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2013-01-02 | E-GEOD-39478 | biostudies-arrayexpress
TranscriptomicsKLF2-Regulated Gene Expression in Mouse Embryonic Yolk Sac Erythroid Cells
KLF2 is a Krüppel-like zinc-finger transcription factor required for blood vessel, lung, T-cell, and erythroid development. KLF2-/- mice die by embryonic day 14.5 (E14.5), due to hemorrhaging and heart failure. Embryonic -like globin gene expression is reduced in KLF2-/- embryos compared to wildtype...
ORGANISM(S): Mus musculus 
2011-03-02 | E-GEOD-27602 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse keratinocytes infected with AD and Ad-NotchIC viruses reveals cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-renewal. Here we show that p63 expression is suppressed by Notch1 a...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5229 | biostudies-arrayexpress
TranscriptomicsLoss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance
The dismal lethality of lung cancer is due to late stage at diagnosis and inherent therapeutic resistance. The incorporation of targeted therapies has modestly improved clinical outcomes, but the identification of new targets could further improve clinical outcomes by guiding stratification of poor-...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-28282 | biostudies-arrayexpress
TranscriptomicsProtective unfolded protein response in human pancreatic beta cells transplanted into mice
Islet transplantation exposes beta cells to mild hyperglycemia and to the abnormal environment of the transplant site. These conditions may affect beta cells and induce the expression of genes involved in beta cell damage. Gene expression profile of human beta cells exposed to mild hyperglycemia by ...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-22097 | biostudies-arrayexpress
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