Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: G Paolo Dotto
PROVIDER: E-GEOD-5229 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Genes & development 20060401 8
Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-renewal. Here we show that p63 expression is suppressed by Notch1 activation in both mouse and human keratinocytes through a mechanism independent of cell cycle withdrawal and requiring down-modulation of selected interferon-responsive genes, including IRF7 and/or IR ...[more]