Reddyhoff2015 - Acetaminophen metabolism and toxicity
This model examines acetaminophen metabolism and related hepatotoxicity. Multiple pathways associated with APAP metabolism has been included in the model. Using numerical, sensitivity and timescale analysis, key parameters invo...
Toxicity of dichlorvos (DDVP), an organophosphate (OP) pesticide, classically results from modification of the serine in the active sites of cholinesterases. However, DDVP also forms adducts on unrelated targets such as transferrin and albumin, suggesting that DDVP causes cellular perturbation by mo...
5 human fecal gut samples, collected and prepared for standard MudPIT data collection from healthy volunteers, searched with the ComPIL database. x3 replicates each