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TranscriptomicsTranscription profiling of rat dentate gyrus samples following passive avoidance learning
Gene expression in the rat dentate gyrus following passive avoidance training.
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-GEOD-1095 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of long term potentiation in rat dentate gyrus
In vivo high frequency stimulated of left dentate gyrus was performed on anaesthetised rats followed by RNA-seq to study long-term potentiation. Both left and right dentate gyrus was collected, sequenced and compared against each other for naive rats and for rats 30 min, 2 hours, and 5 hours post-HF...
ORGANISM(S): Rattus norvegicus 
2015-10-20 | E-MTAB-3375 | biostudies-arrayexpress
TranscriptomicsMolecular regulation in the hippocampal dentate gyrus in the onset and treatment of depression
Major depression is a multidimensional disorder highly prevalent in modern society. Although several classes of antidepressants (ADs) are currently available to treat depression, the effectiveness of treatment is still limited, as many patients do not show full remission; thus, there is a need to fi...
ORGANISM(S): Rattus norvegicus 
2015-07-02 | E-GEOD-56028 | biostudies-arrayexpress
TranscriptomicsAlterations in mRNA levels in the dentate gyrus in epileptic rats
Analysis of the dentate gyrus of amygdala electrical stimulation model of temporal lobe epilepsy. Results provide insight into the molecular mechanism underlying epileptogenesis. This study was designed to estimate changes in gene expression levels after 7 and 30 days after electrical stimulation of...
ORGANISM(S): Rattus norvegicus 
2013-08-14 | E-GEOD-49849 | biostudies-arrayexpress
TranscriptomicsAlterations in miRNA levels in the dentate gyrus in epileptic rats
Analysis of the dentate gyrus of amygdala electrical stimulation model of temporal lobe epilepsy. Results provide insight into the molecular mechanism underlying epileptogenesis. This study was designed to estimate changes in miRNA expression levels after 7, 14, 30 and 90 days after electrical stimu...
ORGANISM(S): Rattus norvegicus 
2013-08-14 | E-GEOD-49850 | biostudies-arrayexpress
ProteomicsDifferential proteomics of the synaptosomal fraction from rat dentate gyrus identified the changes associated with aging-dependent cognitive decline
The study contained three groups of Sprague-Dawley male rats – two groups of aging animals (22-24 months) separated based on performance in spatial reference memory task; and the third, control group of young animals () not separated by behavioural testing. The synaptosome – enriched membrane fracti...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-08-19 | PXD013172 | Pride
Dentate gyrus Spatial reference memory Quantitative proteomics 
TranscriptomicsDifferential expression of stem cell-specific genes in P7 and P28 dentate gyrus neural progenitors
In order to identify cell-autonomous factors that might be regulating the neurogenic niche, type 1 and 2 progenitors were FACS sorted from P7 and P28 animals and their cDNA was hybridized to a stem cell-specific microarray. Keywords: differential gene expression analysis Two samples per microarray ...
ORGANISM(S): Mus musculus 
2009-03-10 | E-GEOD-15085 | biostudies-arrayexpress
TranscriptomicsGene expression microarray analysis on the dentate gyrus of Schnurri-2 knockout and wild-type control mice
Schnurri-2 (Shn-2), an NF-kappa B site-binding protein, tightly binds to the enhancers of major histocompatibility complex (MHC) class I genes and inflammatory cytokines, which have been shown to harbor common variant single nucleotide polymorphisms associated with schizophrenia. Shn-2 knockout mice...
ORGANISM(S): Mus musculus 
2013-08-13 | E-GEOD-42777 | biostudies-arrayexpress
TranscriptomicsLysophosphatidic acid receptor expression identifies a pure population of adult hippocampal stem cells with an immune cell-related transcriptional profile
Lysophosphatidic acid receptor 1 (LPA1) is a phospholipid which has been linked to adult hippocampal neurogenesis and learning deficits. Here we investigated whether LPA acts directly on the hippocampal stem cells and whether LPA1 could be a functional marker for their prospective isolation. Our res...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-68270 | biostudies-arrayexpress
ProteomicsProteomics of the dentate gyrus reveals semantic dementia specific molecular pathology
Background Semantic dementia (SD) is a subtype of frontotemporal dementia (FTD) characterized by language deficits due to severe temporal lobe degeneration. The consistent neuropathological diagnosis is FTD-TDP subtype C, with characteristic round TDP-43 protein inclusions in the dentate gyrus. Desp...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD033060 | Pride
Semantic dementia Proteomics Mass spectrometry Frontotemporal dementia Tdp-43 
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