Sort   by:  
 Page size 
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
GenomicsDeoxyguanosine Kinase Deficiency Couples Purine Metabolism to Innate Immune Activation and Lipid Accumulation in Hepatocytes
Deoxyguanosine Kinase Deficiency Couples Purine Metabolism to Innate Immune Activation and Lipid Accumulation in Hepatocytes
PRJNA1363757 | ENA
ProteomicsFascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments/The mitochondrial deoxyguanosine kinase is required for the self-renewal of cancer stem-like cell in lung adenocarcinoma
Project 1: The deregulation of the actin cytoskeleton has been extensively studied in metastatic dissemination. However, the post-dissemination role of the actin cytoskeleton dysregulation is poorly understood. Here we report that fascin, an actin-bundling protein, promotes lung cancer metastatic co...
ORGANISM(S): Homo sapiens (Human) 
2019-09-12 | PXD014753 | Pride
Mitochondria Actin cytoskeleton Deoxyguanosine kinase Metastasis Fascin Lung cancer Stem-like cells 
UnknownDeoxyguanosine kinase deficiency: natural history and liver transplant outcome.
Not available
S-EPMC11098040 | biostudies-literature
UnknownRecurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.
Not available
S-EPMC4874872 | biostudies-literature
UnknownMitochondrial deoxyguanosine kinase is required for female fertility in mice.
Not available
S-EPMC10984852 | biostudies-literature
UnknownGene therapy prevents hepatic mitochondrial dysfunction in murine deoxyguanosine kinase deficiency.
Not available
S-EPMC11782815 | biostudies-literature
TranscriptomicsDeoxyguanosine Kinase Deficiency Couples Purine Metabolism to Innate Immune Activation and Lipid Accumulation in Hepatocytes
Mitochondrial DNA depletion syndromes (MDS) encompass a heterogeneous set of metabolic disorders caused by defects in enzymes responsible for maintaining mitochondrial nucleotide pools and genome integrity. Among these, deoxyguanosine kinase (DGUOK) acts within the mitochondrial purine-salvage pathw...
ORGANISM(S): Homo sapiens 
2025-11-18 | GSE309813 | GEO
UnknownDeoxycytidine kinase and deoxyguanosine kinase of Lactobacillus acidophilus R-26 are colinear products of a single gene.
Not available
S-EPMC26141 | biostudies-literature
UnknownThe mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma.
Not available
S-EPMC6895611 | biostudies-literature
Sort   by:  
 Page size