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ProteomicsA Nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation
Fascin-1 mediated actin-bundling activity is central to the generation of plasma membrane protrusions required for cell migration. Dysregulation of cellular protrusions is observed in metastatic cancers, where they are required for increased invasiveness, and this is often correlated with overexpres...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD038713 | Pride
Fascin-1 Hydrogen deuterium exchange Nanobody Hdx 
TranscriptomicsRNAi profiling of human fascin knockdown esophageal squamous carcinoma cells
Fascin, an actin-binding protein, is upregulated in a variety of cancers, including esophageal squamous cell carcinoma (ESCC) and is proposed to function in cellular growth, mobility and invasiveness. Nonetheless, the molecular mechanisms through which fascin expression contributes to the proliferat...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-11373 | biostudies-arrayexpress
ProteomicsFascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments/The mitochondrial deoxyguanosine kinase is required for the self-renewal of cancer stem-like cell in lung adenocarcinoma
Project 1: The deregulation of the actin cytoskeleton has been extensively studied in metastatic dissemination. However, the post-dissemination role of the actin cytoskeleton dysregulation is poorly understood. Here we report that fascin, an actin-bundling protein, promotes lung cancer metastatic co...
ORGANISM(S): Homo sapiens (Human) 
2019-09-12 | PXD014753 | Pride
Mitochondria Actin cytoskeleton Deoxyguanosine kinase Metastasis Fascin Lung cancer Stem-like cells 
ProteomicsEffects of FSCN1 inactivation on protein expression in human adrenocortical cancer cells
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 in e...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-18 | MSV000090738 | MassIVE
TranscriptomicsTranscription profiling of mouse untreated melanoma B16F1 cells vs control
B16F1 cells are a good model to study cell motility and cytoskeletal organization. In our lab, a combination of microscopy and gene silencing was used to approach the problem. Having gene expression profiles for B16F1 would facilitate and support subsequent gene silencing by RNAi as well as potentia...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4819 | biostudies-arrayexpress
TranscriptomicsGene expression profile analysis for the Fascin knockdown esophageal squamous carcinoma cells
Fascin, an actin-binding protein, is upregulated in a variety of cancers, including esophageal squamous cell carcinoma (ESCC) and is proposed to function in cellular growth, mobility and invasiveness. Nonetheless, the molecular mechanisms through which fascin expression contributes to the proliferat...
ORGANISM(S): Homo sapiens 
2008-05-08 | GSE11373 | GEO
ProteomicsProteomics analysis identifies IRSp53 and Fascin as critical for PRV egress and direct cell-cell transmission
Pseudorabies virus (PRV) has been widely used as a live transsynaptic tracer for mapping neuronal circuits. Systematically identifying mature PRV virion proteomes and defining copurified host proteins are necessary to fully understand the detailed mechanism underlying PRV transmission p...
ORGANISM(S): Mus Musculus 
2019-09-18 | PXD015490 |
TranscriptomicsTranscription profiling of human Hep3B cells transfected with L1CAM
To compare the transcription profiling between empty vector transfected Hep3B and L1CAM transfected Hep3B
ORGANISM(S): Homo sapiens 
2011-08-01 | E-MEXP-1357 | biostudies-arrayexpress
UnknownNuclear fascin regulates cancer cell survival.
Not available
S-EPMC9427113 | biostudies-literature
UnknownHow does fascin promote cancer metastasis?
Not available
S-EPMC7854785 | biostudies-literature
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