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ProteomicsA Nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation
Fascin-1 mediated actin-bundling activity is central to the generation of plasma membrane protrusions required for cell migration. Dysregulation of cellular protrusions is observed in metastatic cancers, where they are required for increased invasiveness, and this is often correlated with overexpres...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD038713 | Pride
Fascin-1 Hydrogen deuterium exchange Nanobody Hdx 
ClinicalSignificance of Immunohistochemical Expression of Fascin-1 in Colorectal Carcinoma
Colorectal carcinoma is a major health problem. As a malignant tumor, the malignant potential of colorectal carcinoma is based mainly on its ability to metastasis to different sites. Fascin-1 is an actin binding protein which is involved in reconstruction of intracellular actin network, the latter e...
2749335 | ecrin-mdr-crc
ProteomicsEffects of FSCN1 inactivation on protein expression in human adrenocortical cancer cells
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 in e...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-18 | MSV000090738 | MassIVE
UnknownFascin 1 is dispensable for developmental and tumour angiogenesis.
Not available
S-EPMC3828765 | biostudies-literature
UnknownStudying the role of fascin-1 in mechanically stressed podocytes.
Not available
S-EPMC5577297 | biostudies-literature
UnknownA novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability.
Not available
S-EPMC3488970 | biostudies-literature
UnknownStructural Analysis of Human Fascin-1: Essential Protein for Actin Filaments Bundling.
Not available
S-EPMC9224989 | biostudies-literature
UnknownThe actin-bundling protein Fascin-1 modulates ciliary signalling.
Not available
S-EPMC10485897 | biostudies-literature
UnknownFascin-1 in Cancer Cell Metastasis: Old Target-New Insights.
Not available
S-EPMC10379093 | biostudies-literature
UnknownFascin-1 enhances experimental osteosarcoma tumor formation and metastasis and is related to poor patient outcome.
Not available
S-EPMC6337773 | biostudies-literature
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