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TranscriptomicsTDP-43 Neurotoxicity in late D. melanogaster pupae
The aim of this study is to understand the mechanisms of TDP-43 neurotoxicity. Here, we perform a RNA-Seq analysis in TDP-43 gain-of-fucntion (GOF) , TDP-43 loss-of-function and wild-type late pupae heads (73-90 hours APF) and perform TDP-43 GOF vs wild type and TDP-43 LOF vs wild-type differential...
ORGANISM(S): Drosophila melanogaster 
2013-01-22 | E-GEOD-42844 | biostudies-arrayexpress
ProteomicsLoss of phospholipase PLAAT3 causes a mixed lipodystrophic and neurological syndrome due to impaired PPAR𝛾 signaling
PLAAT3 is a phospholipid modifying enzyme predominantly expressed in neural and white adipose tissue (WAT). It is a potential drug target for metabolic syndrome as Plaat3 deficiency in mice protects against diet-induced obesity. We identified seven patients from four unrelated consanguineous familie...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-29 | PXD038815 | Pride
Loss of phospholipase plaat3 causes a mixed lipodystrophic and neurological syndrome due to impaired ppar𝛾 signaling 
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