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TranscriptomicsAdult zebrafish: cornea vs dermis
Transcriptional profiling of adult zebrafish cornea against dermis as a reference. Three biological repeats with dye swap (6 chips of 1x22k for 6 data sets).
ORGANISM(S): Danio rerio 
2015-02-19 | E-GEOD-24593 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse dermis from epithelial activated beta-catenin mutant embryo
β-catenin signaling is required for hair follicle development, but it is unknown whether it is sufficient to activate expression of hair follicle genes in embryonic skin. To address this we profiled gene expression in dermis from E15.5 KRT14-Cre Ctnnb1(Ex3)fl/+ embryos carrying an activating mutati...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-10727 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skin, dermis, and epidermis of epithelial activated beta-catenin mutant embryo
This SuperSeries is composed of the following subset Series:; GSE10726: Expression data from skin of epithelial activated beta-catenin mutant mouse embryo; GSE10727: Expression data from dermis of epithelial activated beta-catenin mutant mouse embryo; GSE10728: Expression data from epidermis of epit...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-10733 | biostudies-arrayexpress
TranscriptomicsAdult epidermal Notch activity induces dermal accumulation of stromal cells
K14NICDER transgenic and wildtype littermate mice were treated with 4OHT for 14 days to activate the transgene Epidermis and dermis preparations from Transgenic and Wild type mice plus whole skin We sought to compare gene expression patterns in K14NICDER transgenic epidermis and dermis to wild type ...
ORGANISM(S): Mus musculus 
2010-09-15 | E-GEOD-23782 | biostudies-arrayexpress
ProteomicsNovel skin photoageing biomarkers of epidermis and dermis revealed by traditional relative quantification in combination with a novel peptide locational fingerprinting MPLF.
Human skin undergoes profound structural remodelling following chronic exposure to ultraviolet radiation (UVR) – photoageing - that is normally studied by comparing photoexposed and photoprotected skin sites. Whilst it is well established that the abundance and distribution of major dermal extracell...
ORGANISM(S): Homo sapiens (Human) 
2021-04-09 | PXD021194 | Pride
#skin #epidermis #dermis #biomarkers 
TranscriptomicsComparison of cornea to the surface tissues, dermis and epidermis, in adult zebrafish
The gene expression profile of the adult zebrafish cornea was assessed in comparison to those from closely associated surface tissues: the dermis and epidermis. This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Danio rerio 
2015-02-19 | E-GEOD-24599 | biostudies-arrayexpress
TranscriptomicsDermal reprogramming through epidermal activation of beta-catenin
Hair follicle formation depends on reciprocal epidermal-dermal interactions and occurs during skin development, but not in adult life. This suggests that the properties of dermal fibroblasts change during postnatal development. To examine this, we used a PdgfraEGFP mouse line to isolate GFP-positive...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-32966 | biostudies-arrayexpress
TranscriptomicsDirect genesis of functional rodent and human Schwann cells from skin mesenchymal precursors (human)
Recent reports of directed reprogramming have raised questions about the stability of cell lineages. Here, we have addressed this issue, focusing upon skin-derived precursors (SKPs), a dermally-derived precursor cell. We show by lineage tracing that murine SKPs from dorsal skin originate from mese...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57518 | biostudies-arrayexpress
TranscriptomicsExtraction of high-quality epidermal RNA after NH4SCN induced dermo-epidermal separation of 4 mm human skin biopsies
To obtain a separation of the epidermal and dermal compartments in order to examine compartment specific biological mechanisms in the skin we incubated 4 mm human skin punch biopsies in ammonium thiocyanate (NH4SCN). We wanted to test 1) the histological quality of the dermo-epidermal separation obt...
ORGANISM(S): Homo sapiens 
2010-03-03 | E-GEOD-15101 | biostudies-arrayexpress
ProteomicsECM composition dictates the mode of cell competition and competence for tumor initiation
The skin epidermis is constantly renewed throughout life1,2. Disruption of the balance between renewal and differentiation can lead to uncontrolled growth and tumour initiation3. Basal cell carcinoma (BCC) is the most frequent cancer in human4,5. Cell competition, the elimination of less fit cells b...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-27 | PXD041644 | Pride
Ecm Bcc Live imaging Tumor initiation Cell competition 
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